Maximum Academic Press #VNS Baseline epiretinal macrophage-like cell density on OCTA predicts anti-VEGF treatment outcomes in branch retinal vein occlusion. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0037 #BRVO #AntiVEGF #OCTA
MAP-Medicine
by @mapjournals.bsky.social
Updates from MAP’s open access journals—Visual Neuroscience, Gastrointestinal Tumors & Journal of Smoking Cessation—covering neuroscience, oncology & public health. #OpenAccess #MedScience
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Maximum Academic Press Maximum Academic Press #VNS Meta-analysis plus multicenter validation yields nomograms that let non-ophthalmic clinicians stratify vision-threatening diabetic retinopathy risk. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0036 #DiabeticRetinopathy #Nomogram #RiskPrediction
Maximum Academic Press #VNS Single-dose 0.01% atropine in pseudophakic myopic children: OCT/OCTA tracks short-term neurovascular and choroidal changes at 1 and 24 h. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0039 #Atropine #Myopia #OCTA
Maximum Academic Press #GIT Validated logistic model predicts anxiety (80.1% incidence) in first-degree relatives of colorectal cancer patients via education, age, comorbidity, and risk perception. Details: https://www.maxapress.com/article/doi/10.48130/git-0026-0012 #ColorectalCancer #Anxiety #PredictiveModel
Maximum Academic Press #JSC RCT: 36 supervised vigorous-intensity cycling sessions added to group CBT before quit date—effects on abstinence in tobacco use disorder. Details: https://www.maxapress.com/article/doi/10.48130/jsc-0026-0007 #SmokingCessation #VigorousExercise #CBT
Maximum Academic Press #VNS Aqueous humor metabolomics links methionine-cycle dysregulation and reduced betaine to proliferative diabetic retinopathy and microvascular alterations. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0038 #DiabeticRetinopathy #Metabolomics #Betaine #Retina
Maximum Academic Press #VNS Novel RPE65 variants disrupt inner retina via VGF loss in LCA; AQEE-30 peptide rescues ganglion cell layer without photoreceptor recovery. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0035 #RPE65 #LCA
Maximum Academic Press #VNS Vascularized retinal organoids integrating co-culture, bioprinting, and organ-on-chip recapitulate neovascular retinopathy for drug screening. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0034 #RetinalOrganoids #Retinopathy
Maximum Academic Press #VNS UK Biobank cohort and Mendelian randomization reveal causal links between inflammatory bowel disease and uveitis/AMD, identifying 49 pleiotropic variants as a mediating pathway. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0029 #GutEyeAxis #IBD #OcularComorbidities
Maximum Academic Press #GIT Evidence-based nursing protocol for CAR-T dermatologic adverse events in pancreatic cancer: dynamic monitoring, CRP/IL-6 correlation with severity, and complete resolution by Day 14 in 4 of 5 patients. Details: https://www.maxapress.com/article/doi/10.48130/git-0026-0010 #DermatologicToxicity
Maximum Academic Press #VNS Multicenter RCT shows repeated low-level red light therapy outperforms 0.01% atropine for childhood myopia control, with 0.42 mm less axial elongation and choroidal thickening of 21.09 micrometers. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0030 #RLRLTherapy #Atropine #RCT
Maximum Academic Press #GIT WGCNA and machine learning identify CDRT15P1 as candidate hub gene in gastric adenocarcinoma; knockdown affects proliferation, migration, and invasion, implicating proteasome pathways. Details: https://www.maxapress.com/article/doi/10.48130/git-0026-0011 #GastricCancer #HubGenes #CDRT15P1
Maximum Academic Press #VNS FAERS disproportionality analysis across 2004-2023 identifies 51 drugs associated with papilledema, with tetracycline, cytarabine, and medroxyprogesterone acetate as highest-risk by BCPNN ranking. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0028 #Papilledema #DrugSafety
Maximum Academic Press #VNS ICL implantation in high myopia reduces accommodation amplitude from 13.33 D to 10.00 D and near negative fusional vergence from 21 to 16 prism diopters at one week. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0025 #ICLImplantation #Accommodation #Vergence #HighMyopia
Maximum Academic Press #VNS Baseline vascular SHRM volume independently predicts worse VFQ-25 composite score after anti-VEGF therapy in nAMD, adding 8.0% incremental variance beyond visual acuity and clinical covariates. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0023 #OCT #NeovascularAMD #AntiVEGF
Maximum Academic Press #GIT Icaritin suppresses HCC by inhibiting ALDOB-mediated glycolysis, reducing histone lactylation on STAT3 promoter via a novel metabolism-epigenetics pathway. Details: https://www.maxapress.com/article/doi/10.48130/git-0026-0009 #LiverCancer #CancerMetabolism #Epigenetics
Maximum Academic Press #VNS Mediation Mendelian randomization identifies CX3CL1 as consistent mediator from TRAb to Graves' ophthalmopathy, with CXCL10 and TNF-beta also significant. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0022 #GravesOphthalmopathy #Randomization #CX3CL1
Maximum Academic Press #VNS Sortilin deficiency alters baseline retinal homeostasis and attenuates p75NTR injury signaling but does not protect against optic nerve crush-induced ganglion cell loss. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0032 #RetinalNeurodegeneration #Sortilin #OpticNerveCrush
Maximum Academic Press #VNS Antagomir-9 silencing of miR-9 in developing rat retina reduces ganglion cell number, and disrupts both vertical and horizontal signaling pathways critical. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0031 #miRNA #RetinalDevelopment #Antagomir
Maximum Academic Press #VNS ZJHY formula protects against diabetic retinopathy and nephropathy by reversing GPR83 upregulation and restoring GPR83-ADM2-AKT axis, with a five-gene immune marker for joint DR-DN screening. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0026 #DiabeticRetinopathy #ZJHYFormula
Maximum Academic Press #VNS Three-year OCT cohort of 1,500 T2DM patients reveals longer axial length, poorer visual acuity, and greater baseline GCIPL thickness as independent predictors of retinal layer thinning. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0027 #OCT #DiabeticRetinopathy #GCIPL
Maximum Academic Press #VNS Recombinant human NGF eye drops achieve 95.2% corneal epithelial healing and nerve regeneration in neurotrophic keratitis at Week 56. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0024 #NeurotrophicKeratitis #Ophthalmology
Maximum Academic Press #VNS Adaptive optics and OCTA reveal photoreceptor disorganization in RP patients and pre-symptomatic changes in carriers; cilia-related mutations show thickest choroid. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0033 #RetinitisPigmentosa #AdaptiveOptics #OCTA
Maximum Academic Press #JSC Korean young adults are 3.6× more likely to quit tobacco than Chinese; gender traditionalism predicts cessation oppositely across the two nations, demanding culturally tailored interventions. Details: https://www.maxapress.com/article/doi/10.48130/jsc-0026-0005 #Tobacco #EastAsia #PublicHealth
Maximum Academic Press #VNS TNF-alpha suppresses Muller cell reprogramming in glaucoma by activating Hippo and inhibiting Wnt/beta-catenin pathways; TNFR1 blockade with R7050 restores proliferation. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0021 #Glaucoma #MüllerCells #HippoSignaling #Wnt
Maximum Academic Press #VNS Intravitreal dopamine overdose reduces sustained superior colliculus responses by ~50% while preserving transient onset/offset signals, supporting DA's role. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0019 #Dopamine #Retina #SuperiorColliculus
Maximum Academic Press #GIT GLT8D1 upregulation drives gastric cancer invasion via IL6/STAT3 activation—new prognostic biomarker predicting poor overall survival. Details: https://www.maxapress.com/article/doi/10.48130/git-0026-0008 #GastricCancer #GLT8D1 #STAT3 #CancerBiomarker
Maximum Academic Press #VNS Literature review of 80 cases establishes ATTRG83R as ocular-predominant amyloidosis with vitreous opacity as initial manifestation, requiring awareness of progressive complications. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0018 #VisualNeuroscience #Ophthalmology
Maximum Academic Press #VNS Thicker ELM-ISOS photoreceptor pattern in myopia associates with 1.79-fold increased retinal detachment risk, offering novel OCT-based risk assessment indicators. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0017 #VisualNeuroscience #Ophthalmology
Maximum Academic Press #GIT Case report identifies SMARCA4-deficient hepatocellular carcinoma as an aggressive malignancy with complete protein loss, highlighting needs for incorporating molecular diagnostics. Details: https://www.maxapress.com/article/doi/10.48130/git-0026-0006 #Gastrointestinal #CancerResearch
Maximum Academic Press #GIT IL-9-expressing Claudin18.2 CAR-T cells show enhanced solid tumor control via improved infiltration, persistence, and antitumor immunity in mouse models. Details: https://www.maxapress.com/article/doi/10.48130/git-0026-0007 #Gastrointestinal #CancerResearch
Maximum Academic Press #VNS Prophylactic vitrectomy timing in acute retinal necrosis should align with fundus visibility and structural risk evolution rather than fixed post-diagnosis timepoints. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0020 #RetinalNecrosis #Vitrectomy #Ophthalmology
Maximum Academic Press #VNS ChemR23 activation protects retinal neurons in diabetic mice by interacting with PTEN, reducing inflammation and Muller cell overactivation. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0012 #Retina #DiabeticRetinopathy #Neuroprotection
Maximum Academic Press #VNS A 3D SS-OCTA radiomics and deep learning fusion model predicts nonperfusion area progression in retinal vein occlusion with AUC of 0.794, outperforming 2D and clinical biomarkers. Detail: https://www.maxapress.com/article/doi/10.48130/vns-0026-0013 #Ophthalmology #DeepLearning #RetinalImaging
Maximum Academic Press #JSC Young Chinese smokers perceive e-cigarettes as reduced-harm based on sensory experience and social media rather than formal health info, leading to risky dual-use behaviors. Detail: https://www.maxapress.com/article/doi/10.48130/jsc-0026-0003 #ECigarettes #TobaccoHarmReduction #PublicHealth
Maximum Academic Press #VNS Elevated cortisol & aldosterone in aqueous humor linked to glaucoma pathophysiology, revealing new therapeutic targets. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0004 #humor #target #link
Maximum Academic Press #VNS Steroid hormone-linked genes HSPA8 & PTGDS identified as potential biomarkers for glaucoma diagnosis and therapy. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0001 #steroid #genes #diagnosis #therapy
Maximum Academic Press #GIT New evidence-based framework for early mobilization after laparoscopic gastric cancer surgery improves postoperative recovery 🏥💪 Details: https://www.maxapress.com/article/doi/10.48130/git-0026-0002 #gastriccancer #newevidence #cancersurgery
Maximum Academic Press #VNS Retinal sublayer thinning progresses with type 2 diabetes severity, with macular thickness and photoreceptor layer changes predicting incident diabetes risk over 11-year follow-up. Detail: https://www.maxapress.com/article/doi/10.48130/vns-0026-0014 #DiabeticRetinopathy #PredictiveBiomarkers
Maximum Academic Press #VNS Asia-Pacific experts release new guidelines for myopia control contact lenses to combat rising childhood myopia rates. Details: https://www.maxapress.com/article/doi/10.48130/vns-0026-0009 #asiapacific #myopiacontrol #contactlenses