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Cutting-edge research, news, commentary, and visuals from the Science family of journals. https://www.science.org

The cover illustrates the trafficking of regulatory immunoglobulin A (IgA)–producing plasma cells (purple) from the gut mucosa to the bloodstream during treatment with anti-CD20 monoclonal antibodies (turquoise) for multiple sclerosis (MS). Credit: Ella Maru Studio
Oldest known Mars rock offers glimpse of planet’s watery youth
The image is a light micrograph of a colon adenocarcinoma. Credit: WebPathology/Science Source
Strontium isotope ratios from 152 individuals, interpreted with an African isoscape and constrained by historical and ancient DNA evidence, indicate diverse origins. Most likely came from near-coastal regions in western Central Africa, but a substantial number show signatures pointing to origins far inland, implying forced movement over hundreds of kilometers. High-resolution intratooth profiles document displacement during childhood.
This month’s cover is a photograph of a quadrupedal robot jumping over a fallen tree trunk. Credit: Hyungjoon Jeon
An illustration of a man reaching his hands across a desk to another man who is crying, with text: How I hold space for crying in the workplace
Based on forensic analysis, this illustration depicts the Cerro El Plomo child high in the Andes during an Inca Capacocha, his head lowered as a ritual officiant raises a blunt weapon. Credit: Katiushka Loyola Romero. Scientific guidance: Verónica Silva-Pinto, Universitat de València.
Line chart showing the maternal mortality rate for Malawi, sub-Saharan Africa, and the world from 1985 to 2023. In 1985, the rates for Malawi and sub-Saharan Africa were around 1100 per 100,000 live births, much higher than the global rate of about 450. The rates for Malawi and sub-Saharan both fell over time, but Malawi's fell more sharply, and was close to the global rate of 200 in 2023. There is a spike in Malawi's rate around 2010, but it may be an artificial spike caused by incomplete data from 2003 to 2018.
Chatbots can help perpetuate stigma around certain health conditions Negative perceptions of mental illness and other health issues subtly shape outputs from large language models
The image shows a cross section through the colon of a mouse with chemically induced colitis. Credit: Li et al./Science Signaling
Tree-killing beetle is spreading to urban forests around the world As researchers piece together the pest’s global trek, countries are working to contain the growing threat
The cover illustrates two juxtaposed microscopic "ecological gardens," visually representing two distinct fates of the nasopharyngeal microecology in the context of nasopharyngeal carcinoma (NPC), as well as the potential for ecological remodeling through immunotherapy. The garden on the right represents a microbial community associated with favorable clinical prognosis. The sunlight and rain symbolize anti–PD-1 immunotherapy. Credit: Ying-Qi Lu
Ancient DNA solves Medici murder mystery. Malaria, not poisoning, killed a prominent 16th century duke.
Sergey Stavisky
The image shows skulls and lower jaws from several living and extinct mammal species, highlighting differences in size, shape, and feeding adaptations. Featured specimens include an extinct saber-toothed cat alongside extant species. This subset highlights specimens that were specialized in either crushing or slicing as well as a species of civet that was balanced in both functions. Photo: Melvin Vankelst
Plan to turn major monkey research facility into sanctuary may be dead
Spain's largest research organization confronts its dark past.
A conceptual illustration with two people separated by a winding path full of icons representing life milestones, with the text: To my younger self, the overwhelmed new professor: You will make it
Study dampens hope that meningitis vaccine can also prevent gonorrhea
Map of the United States showing the ranges of the barred owl, northern spotted owl, and California spotted owl. Pre-1900, barred owls lived only in the east, but they expanded west in the 20th century, mostly in Canada. In recent decades, barred owls have moved south along the west coast, into forests historically occupied by the northern spotted owl and California spotted owl. Many spotted owls have been displaced in the areas where the spotted and barred ranges overlap, which is most of the spotted owls' ranges. Over the past 5 years, scientists have killed more than 2000 barred owls in Northern California in an attempt to create a spotted owl safe zone.
NSF makes billion-dollar gamble on research with an economic payoff
A fruit fly. PHOTO: STEPHEN DALTON/SCIENCE SOURCE
Protein name confusion created antibody mix-up affecting hundreds of papers
Our Changing Seas IV (2016-2019), a glazed stoneware and porcelain artwork. Credit: Our Changing Seas IV (2016-2019) by Courtney Mattison. Glazed stoneware and porcelain. Private collection. © Courtney Mattison
A molecular quirk unique to octopuses makes them better at building proteins
Detection schemes could deter putting nuclear warheads in space
An untethered flapping-wing robot bursts from the water’s surface, transitioning from swimming to flight in a single motion. Photo: Lauren Owens Lambert
Shown is a transmission electron micrograph of a bacteriophage (orange) on an Escherichia coli bacterium (blue). Credit: Biozentrum, University of Basel/Science Source
Archipelago of science. Research facilities span much of Svalbard, supporting studies of glaciers, permafrost, ecosystems, the atmosphere, and the Arctic Ocean. Image: Map of Svalbard showing the locations of various countries' research stations. In the northernmost town of Ny-Ålesund, there are buildings for the Netherlands, the UK, India, Japan, China, France, South Korea, Norway, Italy, France, and Germany. In other locations across Svalbard are additional stations belonging to France, Russia, Czechia, Norway, and Poland.
British ‘First Fleet’ brought smallpox to Australia—and may have killed millions
An illustration of a man writing on a paper with a large pen shaped like the letter I, with text: Instead of banning AI, I made a classroom contract with my students
Inbreeding didn’t doom the Neanderthals, study suggests Analysis of more than two dozen new genomes suggests our closest cousins remained genetically healthy, just before they vanished
This month’s cover illustration depicts an avatar of the immune system playing a memory game, in which previously encountered pathogens are remembered. The scene is framed by an unspooling chromosome, highlighting the critical role that epigenetic reprogramming plays in both innate and adaptive immune memory. Credit: Ada Zejun Shen
Yibin Zhu
Ancient switch to soft food gave us an overbite—and the ability to pronounce ‘f’s and ‘v’s
A reconstruction of the forest floor of the DT flora featuring hypothetical angiosperm-disperser interactions.
Scientists have only discovered a tiny fraction of living insect species.
An illustration of time-frequency entanglement. Credit: Nicoletta Barolini
Students engage in hands-on learning in the biology laboratories at Johns Hopkins University, Baltimore, Maryland, 1920.
Fading melodies Intact tropical forests are seeing mysterious bird declines. Is another “silent spring” brewing?
Migrating sea turtles only sort of know where they’re going
An illustration of a woman riding a large turtle with a stack of papers behind her, with the text: My Ph.D. took a long time—and there’s no shame in that
Quote on a black background stating, "America has for its entire history been fascinated with science." Attributed to H. Holden Thorp, Editor-in-chief of Science journals.
The tallest 1% of trees store more than half the carbon in the world’s forests. It is widely assumed that height limits canopy hydration of tall trees; however, direct evidence that this happens for tall trees such as the Koompassia excelsa, shown here, is lacking. Research on Southeast Asian dipterocarps, the tallest tropical trees, shows that they adjust their hydraulic system as they grow tall, suggesting resilience to drought. Photo: Nick Garbutt/Minden
The cover image shows a scanning electron micrograph of a polymeric microneedle array decorating the surface of a 3D-printed intestinal anastomosis stent. Credit: Zhen Gu, Yuqi Zhang, Ruyi Zhou/Zhejiang University
Engineers cram 100 billion transistors onto a microchip Advance nearly doubles chip density, but also highlights the challenge of sustaining historic trend
Graphic of the structure of cell vaults.
Good news: A nuke can save us from an asteroid In a laboratory experiment, x-rays like those produced by a nuclear explosion vaporized mock space rocks