AJ Martin

@ajmartin.one

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PhD student and harm reduction advocate @brp.org.uk ๐Ÿ’™ Researching neuronal calcium channel regulatory mechanisms: kadurinlab.org ๐Ÿ‘จโ€๐ŸŽ“ ๐Ÿ”— ajmartin.one

Screenshot of our poster details from the BPS Events conference app. Title: LB64 - UNCOVERING A NOVEL AUTOINHIBITORY DOMAIN OF ฮฑ2ฮด SUBUNITS ESSENTIAL FOR FUNCTIONAL MATURATION OF VOLTAGE-GATED CALCIUM CHANNELS Session : Posters: Voltage-Gated Ca Channels (Late) Location : West Exhibit Hall Date : Tuesday, Feb 18 1:45 pm Duration : 2 hours Authors: Alexander J.L. Martin, Najoua Biba, Hannah J. Lee, Dario S. Linklore, Matthew Day, Annette C. Dolphin, Ivan Kadurin. Authors from Department of Biochemistry, QMUL, and Department of Neuroscience, Physiology and Pharmacology, UCL.
An infographic summary of the 3 key findings from the 2019 report on London cost of living. 4 in 10 Londoners have an income below what is needed for a decent socially acceptable living standard. Up to 58% more expensive to reach a decent standard of living in London than in other urban areas of the UK, thanks to housing, childcare and transport costs. 1/3 of all pensioners in London now have incomes below the Minimum Income Standard, up from 1/4 in 2011.
Figure 4C, from Lyndon et al., Addiction. 2017 September ; 112(9): 1580โ€“1589. doi:10.1111/add.13843. AUC analysis of the data in A & B [see ref 18] indicated that in morphine pretreated mice pregabalin + morphine induced significantly greater depression of respiration than morphine alone (P<0.05). N = 6 in each case.
The chemical structures of GABA, compared to gabapentin and pregabalin. Source: Patel and Dickenson, Mechanisms of the gabapentinoids and ฮฑ2ฮด-1 calcium channel subunit in neuropathic pain. Pharmacology Research & Perspectives, 4:2 (2016). DOI:10.1002/prp2.205
A chart showing specific drug-related poisonings in England and Wales between 1993โ€“2023. The green line denotes pregabalin-related deaths, which climb from zero in 2008, 33 in 2013, and 549 in 2023. Comparing this to other common non-opiate drugs, we see that pregabalin-related deaths over the past decade have been consistently higher than MDMA/Ecstasy (blue), have recently surpassed benzodiazepine-related deaths (orange), and have climbed at a similar pace to deaths relating to cocaine (yellow). Data source: Office for National Statistics, Deaths Related to Drug Poisoning in England and Wales: 2023 Registrations (2024).