Alan Murphy

@al-murphy.bsky.social

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Postdoctoral Research Scientist, Koo lab at Cold Spring Harbor Laboratory | Deep Learning for genomics

Enformer Celltyping’s predictions capture cell type-specific genetic enrichment for complex traits - a Heatmap of stratified LD score regression (s-LDSC)73 analysis for genetic variants associated with brain and immune diseases/traits and behavioural traits (sourced from associated GWAS) displayed as false discovery rate (FDR) value for significance of enrichment for ATAC-Seq chromatin accessibility signal, H3K27ac signal and Enformer Celltyping’s (EC) predictions of H3K27ac for microglia, neurons and oligodendrocytes (oligoden.). b -log10(FDR) genetic enrichment for the complex traits from s-LDSC. c Proportion of peaks in derived peak files used for s-LDSC analysis. The median, minima and maxima foe the violin plots were Monocyte; 0.768, 0.380, 0.934, Neutrophil; 0.720, 0.475, 0.925 and T-Cell; 0.737, 0.159, 0.924.