Dr. Ali Barry

@aliibarry.com

1406 Followers 896 Following

Bioinformatician • UTDallas, previously UniOxford & UniWien | pain, proteomics, multi-omics & open science | chronic migraines | raised on unceded Algonquin, Anishinabek territory | she/they 🍁🌈🍉

Photo of an Amovig medication box
Close up photograph of a small tree frog sitting in a yellow rose
Group photo of 20 scientists on the lawn of Kellogg college, Oxford
Ali canoeing with a friend down an overgrown canal with a dog leaning over the front of the boat
Photo of a solo laptop in the Radcliffe Camera (library) at Oxford
Photo of the Giro d'Italia peleton in front of the Colosseum on the final day of the tour
Narrow wooden statue of a woman in a remote mountain saddle. A mix of spring snow and flowers are scattered around the rocky scene.
Landscaped garden view in Verona
View over Verona in the morning sun
Photo of a creek in Dallas from above, surrounded by trees with a short path connecting the view to the pavement
Screenshot from Figure 1C showing an immunohistochemistry of the mouse peripheral nervous system (skin, nerve, DRG, spinal cord) as labelled by a TurboID x AdvillinCre transgenic
Screenshot of the London Marathon ballot entry for 25 April 2027
Page from "Handy things to know (1800)". Ontario: Dr. Hall Medecine Company. Patient story under the header "like a new man", followed by the add titles "DON'T DIE"
Valentine's Day card as a photo of two scientists shrugging and the text "My love for you can't be explained by science. Just like the new federal vaccine guidelines."
Eagle flying close to a pebble beach overed in driftwood
Golden retriever bouncing through the woods facing the camera
Selfie of Ali with they sister, a baby and a puppy on a beach in front of a mountain range
Misty park view with bare tree silhouettes lining an icy path
Mark Carney embracing Hudson Williams in the Heated Rivalry team Canada fleece
Empty apartment with moving boxes scattered around
Cannondale Synapse road bike in front of a bike box for storage
Sunny skies over a groomed piste in Switzerland
Ali sitting in the snow beside a black dog jumping for a snowball in the forest
Snow covered rail tracks in front of a large lake and mountain foothill backdrop
Snowy low mountain valley out a train window
Book Cover of "Art Monsters - Unruly Bodies in Feminist Art" by Lauren Elkin. Cover Art for the book is an image of Blue Eyeliner, 2020 by Genieve Figgis
Christ church meadow at sunset
Blue skies reflecting in a canal with a path along the water
Group of parkrun runners dressed mostly in red and green with Santa hats on a sunny day
Busy start line at parkrun in Battersea park
Group photo of Ali + running friends in the snow above a cloud filled valley
Frozen fountain in a park with blue skies
Group photo from a protest, with signs saying "Fuck love. Pass laws" and "protect trans kids"
Ali dressed in winter running kit on a snowy trail
Worn path through a dry meadow
Patches of snow along a forest path in the mist
Mountain bikes and a golden retriever in a sunny forest. The ground is covered in fallen leaves
Happy golden retriever outside on a drive holding a glove with a wagging tail in the autumn
Photo of a thanksgiving dinner spread.
Grassy park overlooking rolling hills with orange leaves scattered across the trees. There is a bright blue sky, sun touched grass and few white clouds
Photo of the Bennett lab and extended folks at a long table out for dinner.
Screenshot of a train journey with multiple transfers, each delayed, but the timing not adding up.
screenshot of a zoom meeting and a Rmd knit for a "Machine Learning in Neuropathic Pain" document
Alpine view south from Schöntalspitz
Glacier stream running down a mountain valley
Two kittens asleep on a bench beside each other
Adult cat hiding (from her kittens out of view) in a pallet on a deck
Orange black cat looking off into the distance on a bench across from someone's hand holding a coffee. There is a black kitten in the background strutting around.
Young orange cat by a running pack on a deck overlooking a mountain valley
Murine skin section, with biotin-labelled primary afferents intervating the dermal and epidermal layers, as marked by dapi staining
Photo of the Halifax wave at sunrise with a Canadian flag behind
Ali in shorts and a t-shirt on a mountain ridge with glaciers behind
Photo of a mountain valley with a thin trail in loose gravel on the left side of the valley
Figure 1 IHC for the linked paper. Representative immunohistochemistry from TurboIDfl/fl (control) and AdvCre;TurboIDfl/fl mice across tissues. Cyan, DAPI. Magenta, Streptavidin-555 (biotin). Scale bar = 50 μm.
Photograph of "Winterlandschaft" (winter landscape) in a gallery by Edvard Munch
Screenshot of Fig 3 from the paper, showing a schema of the four regions processed - peripheral terminals, axons, somata, and central terminals of DRG sensory neurons with corresponding cellular component and biological pathway enrichments. While neuronal signatures are detected in each compartment, they also show functional specificity, as expected. Primary afferents synapse on secondary order neurons in the dorsal horn of the spinal cord. This corresponds to the enrichment of proteins involved in presynaptic function and synaptic signalling between neurons, as well as vesicle-mediated transport, exocytosis, and other synapse-related terms in the LSC. The DRG contain neuronal somata, and, thus, corresponding functional enrichment matches expectations. Here, we see the enrichment of proteins involved in mRNA processing, post-translational modification, and nuclear structures, in line with the biosynthetic activity expected in neuronal cell bodies. The sciatic nerve consists of neuronal axons, as well as Schwann cells, fibroblasts, endothelial cells, and immune cells. Its neuronal proteome is enriched for myelination, cytoskeletal organization, and vesicle-mediated transport. In the “myelination” terms, we see the presence of nodal and paranodal proteins such as Cntn1 (Contactin-1) and Cntnap1 (Caspr1), as well as more generally expressed neuronal proteins like Ncam1, Nefl, Nefm, and Nefh. We also see proteins more classically associated with myelin itself, such as Plp1, MBP, and MPZ , which also show expression in neuronal subtypes.
Schematic of the linked paper. AdvillinCre; TurboIDfl/fl mouse was used to biotylinate proteins in advillin+ cells (ie. sensory neurons), represented by stars in the schema, which were then enriched (eppendorf clipart) and put into a mass spectrometry (DIA-PASEF) to generate a neuronal-enriched proteome
Photograph from Rathausplatz during pride
Photo of Lovro being interviewed in a pride parade, wearing a trans flag and a keffiyeh