Nastia Lyulina @alyulina.github.io ยท Nov 6 How is functional variation at large-effect loci maintained in natural populations, even as environments change? In a paper led by @mkarag.bsky.social, we tracked known pesticide resistant alleles in outdoor ๐. ๐ฎ๐ฆ๐ญ๐ข๐ฏ๐ฐ๐จ๐ข๐ด๐ต๐ฆ๐ณ cages & inferred selection and dominance from temporal sequencing data.
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Simultaneously inferring both parameters is generally difficult, especially for deleterious alleles. In our experiment, however, costly resistant alleles remained low in unexposed cages; in exposed cages, they rose in frequency with pesticide application and began to decline once it was removed.