Arc Institute @arcinstitute.org · Jun 26 cGAMP and arginine bind separate sites on SLC7A1. The team mutated cGAMP sites without affecting arginine transport, and found that excess arginine alone protects T cells from STING-agonist death.
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Since the two functions are separable, SLC7A1 is an actionable drug target; blocking it could specifically protect T cells during STING agonist therapy while leaving the STING axis in other cell types intact. Access the paper: www.cell.com/cell-reports...