Aligning Science Across Parkinson's

@asapresearch.parkinsonsroadmap.org

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Global initiative to accelerate Parkinson's disease research. Programs include GP2 and CRN. Managed by the Coalition for Aligning Science and part of the CNS Quest. parkinsonsroadmap.org

Global genetic spectrum of PD and locations of clinical trials targeting gene variant carriers.
CRN Team Kirkeby graphic titled “Connecting the Environmental Exposome to Parkinson’s Risk,” with the subtitle “Stem cell screens, exposomics, and registry data to uncover toxicant-linked disease pathways.” The graphic features headshots of Lead PI Agnete Kirkeby, MD, PhD, and Co-PIs Per Borghammer, MD, MSc; Annette Ersbøll, PhD; Nikoline Juul Nielsen, PhD; and Marina Romero-Ramos, PhD.
Workflow of the in-cell lipid uptake assay and comparison of gating strategies.
ALG-2 and CASM as lysosomal damage sensors prevent K18.Tau aggregation.
Q-DOAS assay principle and kinetic readout: Development for polyQ-expanded HTT-Ex1.
Structure of FBXO7-bound OG-20S CP complex.
Levels of GSLs are significantly altered in the plasma of PD patients compared to controls.
Misfolded protein & ischaemic pathology in controls & Lewy body disease.
Lysosomal dysfunction results in GPNMB secretion via lysosomal exocytosis.
Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder.
Behavioral screening reveals 2 groups of Parkinsonism mutants.
Familial PD single cell transcriptomics profiling and molecular features of pluripotent stem cell derived dopamine neurons.
WIBR3 hESC cell line characterization.
Cell morphomics workflow to identify Parkinson’s disease specific cellular signatures.
Behavioral screening reveals 2 groups of Parkinsonism mutants.
WIBR3 hESC cell line characterization.
Familial PD single cell transcriptomics profiling and molecular features of pluripotent stem cell derived dopamine neurons.
Cell morphomics workflow to identify Parkinson’s disease specific cellular signatures.
The SncaG51D/G51D mutation induces age-dependent cilia defects in vulnerable cells of the mouse dorsal striatum.
GP2’s 12th Data Release: By the Numbers. A blue gradient graphic states that the release contains more than 124,942 genotyped participants from around the globe.
CRN Team Greenamyre graphic titled “Uncovering How Environmental Exposures Shape Parkinson’s Heterogeneity,” with the subtitle “Mechanisms of toxicant-driven neurodegeneration and therapeutic mitigation.” The graphic features headshots of Lead PI J. Timothy Greenamyre, MD, PhD, and Co-PIs Sarah Marzi, PhD; Sean Pintchovski, PhD; and Emily Rocha, PhD.
Gradient green, blue, and purple Discover ASAP graphic promoting a talk titled “An Isogenic Single-Cell Atlas of Familial Parkinson’s Disease Mutations,” with a circular speaker headshot and the name Khaja Mohieddin Syed, PhD.
ASAP CRN Cloud graphic with the ASAP and CRN Cloud logos, headline “New CRN Cloud Training Videos,” and text reading “Explore tools, datasets, and resources to support Parkinson’s disease research.” A subtle branching network/tree illustration appears on the right.
Graphic with a light blue and green world map background. On the left is the GP2 Data Resources logo featuring a DNA strand surrounding a globe, with the text "Transforming Global Data Into Discovery" around the logo. On the right, large black text reads "12th Data Release."
Graphic featuring a group photo of Team Bronstein. The team members are labeled as Jeff Bronstein, MD, PhD, Lead PI; Christina M. Lill, MD, MSc, Co-PI; Beate Ritz, MD, PhD, Co-PI; Clive Svendsen, PhD, Co-PI; Chao Peng, PhD, Co-PI; and Lisa Barnhill, PhD, Project Manager. The CRN logo appears in the upper right.
Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder.
Cytoarchitectural identification of the RMTg and RRF/PBP lateral GABAergic cell cluster (LatC) in the human midbrain.
Ultrastructural analysis of LLOMe-damaged lysosomes reveals distinct electron-dense fibrils inside lysosomes.
A light gradient graphic featuring a circular purple-and-blue tree icon on the left. The text reads, “Investigating How Genes and Exposures Shape Parkinson’s Risk,” with the CRN logo in the upper right.
Graphic with a purple-to-blue gradient background titled “Neuronal Resilience and Transcriptional Regulatory Programs.” Subheading: “Decoding gene regulatory mechanisms that drive degeneration or resilience to enable precision therapeutic strategies.” Below are four circular headshots of researchers in the CRN Discovery Fellowship with their affiliations: Jonathan Brenton, PhD (Home: Team Hardy; Host: Team Alessi); Julia (Kate) Brynildsen, PhD (Home: Team Biederer; Host: Team Gradinaru); Raquel Garza Gomez, PhD (Home: Team Jakobsson; Host: Team Voet); and Weiqiang Liu, PhD (Home: Team Scherzer; Host: Team Rio).
Graphic featuring four diagonal panels representing scientific research: a DNA strand, brain imaging scans, laboratory samples being processed with a pipette, and genetic sequencing data. The image is displayed in blue and green tones.
Cardiac contractility dynamics during incentivized reaching.
Graphic introducing Team Ulusoy, part of the Collaborative Research Network. The headline reads, “Developing Precision Antibody Tools for Parkinson’s Research,” with the subhead, “Multiplex-ready antibodies to visualize key disease pathways.” The graphic features circular headshots and names of team members: Ayse Ulusoy, PhD, Lead PI; Jessie Ni, PhD, Co-PI; Philip Denner, PhD, Co-PI; and Geidy Serrano, PhD, Co-PI. The CRN logo appears in the top right on a light lavender-to-white gradient background.
A blue ASAP Open Science Champion graphic featuring a headshot of Elena Coccia, PhD, on the left in a circular frame. White text on the right reads, “Elena Coccia, PhD” and “Team Vangheluwe.” An “Open Science Champion” badge appears near the lower-left edge of the headshot, and a faint ASAP logo appears in the bottom-right corner.
Group photo of conference attendees wearing name badges, posed in two rows in front of a wood-paneled wall. The photo is framed by a purple, blue, and green gradient border.
Graphic introducing Team McDonough, part of the Collaborative Research Network. The headline reads, “Creating High-Quality Stem Cell Models for Emerging Targets,” with the subhead, “Validated iPSC systems to study Parkinson’s at cellular resolution.” The graphic features circular headshots and names of team members: Justin McDonough, PhD, Lead PI; Stefan Semrau, PhD, Co-PI; Valentina Fossati, PhD, Co-PI; and Eva-Maria Surmann, PhD, Co-PI. The CRN logo appears in the top right on a light lavender-to-white gradient background.
The DA-ACh anti-correlation hotspot in aDLS is consistent for dynamics around conditioned cues and for inverse dynamics following extinction.
Graphic with a purple-to-blue gradient background titled “Dopaminergic Circuit Function, Metabolism, and Selective Vulnerability.” Subheading: “Linking circuit dynamics and bioenergetic stress to explain selective vulnerability and restore dopamine function.” Below are six circular headshots of researchers in the CRN Discovery Fellowship with their affiliations: Sayan Dutta, PhD (Home: Team Gradinaru; Host: Team Awatramani); Janko Kajtez, PhD (Home: Team Jakobsson; Host: Team Studer); Christiana Kontaxi, PhD (Home: Team Edwards; Host: Team Awatramani); Mukesh Kumar, PhD (Home: Team De Camilli; Host: Team Edwards); Matthew McGregor, PhD (Home: Team Edwards; Host: Team Surmeier); and Kathryn Todd, PhD (Home: Team Cragg; Host: Team Awatramani).
Graphic with a teal-to-purple gradient background featuring the text, “Analysis of Transposable Elements at Single-Cell Resolution.” A circular headshot of Talitha Forcier, PhD, appears on the right, with their name below. Vertical text on the far right reads, “Discover ASAP.”
Graphic introducing Team Koob, part of the Collaborative Research Network. The headline reads, “Engineering Humanized Models to Understand Parkinson’s Genetics,” with the subhead, “Next-generation mouse models to uncover disease drivers.” The graphic features circular headshots and names of team members: Michael Koob, PhD, Lead PI; Michael Sasner, PhD, Co-PI; Andrew West, PhD, Co-PI; Matthew Goldberg, PhD, Co-PI; and Laura Volpicelli-Daley, PhD, Co-PI. The CRN logo appears in the top right on a light lavender-to-white gradient background.
Graphic with a dark background and the headline, “3K+ Resources. One Catalog.” Five circular icons show resource categories and counts: +600 Articles, +400 Datasets, +700 Lab Materials, +1,300 Protocols, and +170 Codes. The Aligning Science Across Parkinson’s logo appears at the bottom.
Graphic with a purple-to-blue gradient background titled “Neuroinflammation, Genomic Regulation, and Systemic Drivers.” Subheading: “Understanding how systemic and genetic drivers fuel inflammation to unlock immune-targeted and precision approaches.” Below are five circular headshots of researchers in the CRN Discovery Fellowship with their affiliations: M. Elizabeth Deerhake, MD, PhD (Home: Team Hafler; Host: Team Scherzer); James Evans, PhD (Home: Team Wood; Host: Team Studer); Amandine Even, PhD (Home: Team Desjardins; Host: Team Schapira); Alexandra Kazanova, PhD (Home: Team Desjardins; Host: Team Sulzer); and Indrani Poddar, PhD (Home: Team Lee; Host: Team Studer)
Graphic with a purple, blue, teal, and green gradient background. On the left, a circular headshot of Sonya Dumanis appears with a white border and decorative white starburst accents. On the right, large white quote text reads, “Our goal is to bring together people with complementary expertise across different institutions and disciplines to answer research questions collaboratively.” Beneath the quote, the attribution reads, “– Sonya Dumanis, PhD, Managing Director of Aligning Science Across Parkinson’s.” The ASAP logo appears in the lower-left corner.
Graphic with a blue-to-purple gradient background and large white text reading, “Introducing the 2025 MoMa Awardees.” The CRN Collaborative Research Network logo appears centered near the bottom.
Graphic for CRN Team Gijsbers with a light lavender-to-white gradient background. Text reads, “Building Viral Vector Tools to Decode Disease Mechanisms,” with the subhead, “Scalable systems for gene modulation across models.” The CRN Collaborative Research Network logo appears in the top right. Five circular headshots appear below with names and roles: Rik Gijsbers, PhD, Lead PI; Veerle Baekelandt, PhD, Co-PI; Veronique Daniëls, PhD, Co-PI; Peter Loskill, PhD, Co-PI; and Wouter Peelaerts, PhD, Co-PI.
A graphic with a blue-to-green gradient background and a headshot of Andrew Singleton, PhD, on the right side. White text reads: “Andrew Singleton, PhD on What Causes Parkinson’s: A Panel Discussion with MJFF on Genetics, Environment, and Aging.” The GP2 logo appears in the top left corner.
Graphic with a purple-to-blue gradient background titled “Cellular Quality Control and Organelle Dysfunction.” Subheading: “Identifying where quality control fails, and how to rescue it, to inform biomarkers and slow progression.” Below are four circular headshots of researchers in the CRN Discovery Fellowship with their affiliations: Odetta Antico, PhD (Home: Team Alessi; Host: Team Harper); Bishal Basak, PhD (Home: Team Hurley; Host: Team Alessi); Amanda Bentley-DeSousa, PhD (Home: Team De Camilli; Host: Team Harper); and Prosenjit Pal, PhD (Home: Team Alessi; Host: Team De Camilli).
People standing across a colorful background with overlapping circles and brain scan images in the center.
Graphic promoting the GBA1 Parkinson’s Disease Research Catalyst Program. Large gradient text reads “GBA1 Parkinson’s Disease Research Catalyst Program,” with the subhead “Advancing biological understanding of GBA1-associated Parkinson’s disease.” A bottom gradient banner reads, “Now Accepting Full Proposals By July 22,” alongside the ASAP logo.
Graphic for CRN Team Fraser with a light lavender-to-white gradient background. Text reads, “Designing the Next Generation of Parkinson’s Drug Targets,” with the subhead, “Structure-based discovery to accelerate therapeutic development.” The CRN Collaborative Research Network logo appears in the top right. Five circular headshots appear below with names and roles: James Fraser, PhD, Lead PI; Bryan Roth, MD, PhD, Co-PI; Balyn Zaro, PhD, Co-PI; Dmytro Radchenko, PhD, Co-PI; and Per Svenningsson, MD, PhD, Co-PI.
A blue ASAP Open Science Champion graphic featuring a headshot of Kaelyn Long, MSc, on the left in a circular frame. White text on the right reads, “Kaelyn Long, MSc” and “Team Microbiome Analytics Core (MAC).” An “Open Science Champion” badge appears near the lower-left edge of the headshot, and a faint ASAP logo appears in the bottom-right corner.
Graphic featuring a circular illustration of diverse human silhouettes in profile, layered in glowing blue and purple tones against a dark background. To the right, bold text reads: “Mapping Parkinson’s Disease Heterogeneity to Accelerate Discovery,” with “Accelerate Discovery” highlighted in blue. The Collaborative Research Network (CRN) logo appears in the top right corner.
Graphic with a blue-to-green gradient background featuring the text “We’re Hiring” in large white letters. Below, it reads “Project Manager” in bold white font. A white-outlined box on the right says “Application Deadline: June 5, 2026.” The Global Parkinson’s Genetics Program (GP2) logo appears in the upper right corner.
"Graphic for the Collaborative Research Network (CRN) featuring the headline “Advancing Biomarker Tools for Parkinson’s Discovery” and the subheading “Ultrasensitive assays to measure disease biology in blood and CSF.” The graphic highlights Team Ashton and includes headshots and titles for Nicholas Ashton, PhD (Lead PI), Ravindran Kumaran, PhD (Co-PI), Kishore Malyavantham, PhD (Co-PI), and Henrik Zetterberg, MD, PhD (Co-PI). The CRN logo appears in the top right corner. "
Graphic with a green-to-blue-to-purple gradient background. Large white text on the left reads: “A Multi-Omics Dataset Mapping Genetic Enhancer Variants.” On the right are four circular headshots with white borders, labeled Alexandra Pančíková, MSc; Julie De Man, MSc; Koen Theunis, PhD; and Olga Sigalova, PhD. Along the far-right edge, the Discover ASAP logo appears vertically in white with a thin vertical line beneath it.
Graphic with a purple-to-blue gradient background titled “Alpha-synuclein Pathology, Aggregation Kinetics, and Disease Propagation.” Subheading: “Decoding early molecular events to enable earlier intervention and disease-modifying therapies.” Below are four circular headshots of CRN Discovery Fellows with their affiliations: Caroline Haikal, PhD (Home: Team Kaplitt; Host: Team Jakobsson); Eric Herrmann, PhD (Home: Team Hurley; Host: Team Alessi); Patrick Kearney, PhD (Home: Team Gradinaru; Host: Team Schlossmacher); and Naman Vatsa, PhD (Home: Team Biederer; Host: Team Lee).
Graphic with the CRN (Collaborative Research Network) logo and the headline “Building Tools to Accelerate the Next Era of Parkinson’s Discovery.” To the left, a circular illustration shows a mouse on a strand of DNA surrounded by glowing molecular structures, representing scientific research and tool development.