Babraham Institute

@babrahaminst.bsky.social

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We make discoveries that help us understand human biology and improve lifelong health. Leaders in #AgeingResearch and cell biology. Research themes in #Epigenetics, #Immunology and #Signalling šŸ“Œ Cambridge, UK Funded by UKRI-BBSRC

Microscopy image of a day 14 human embryo that has implanted in the new endometrial model.
Labelled black and white thumbnails of four video clips with titles: Cage cleaning, daily visual checks to ensure mouse welfare, Enrichment provision, Health checking our mice.
Text reads: Take a 360 degree tour of our animal facility. Step 1: Visit. Step 2: Pick your route/area of interest. Step 3: Explore!
The graph title is: 2020-2024 Animal Use Statistics: Procedures & Severity The graphic shows a horizontal bar chart showing the breakdown of severity numbers for each year from 2020 to 2024. In 2024, a total of 30,389 procedures were carried out, with 23,257 being sub-threshold, 6,581 being mild, 516 being moderate and 35 being severe. For previous years the data is as follows: In 2023, a total of 33,364 procedures were carried out, with 25,585 being sub-threshold, 7,349 being mild, 375 being moderate and 55 being severe. In 2022, a total of 39,157 procedures were carried out, with 4,069 being sub-threshold, 34,651 being mild, 389 being moderate and 48 being severe. In 2021, a total of 40,750 procedures were carried out, with 4,008 being sub-threshold, 36,093 being mild, 514 being moderate and 135 being severe. In 2020, a total of 48,599 procedures were carried out, with 7,613 being sub-threshold, 40,223 being mild, 664 being moderate and 99 being severe.
Text reads: Frontiers in stem cell innovations, 5 & 6 February 2026 Wellcome Genome Campus and Babraham Research Campus, Cambridge, UK Partnered with the Annual World Organoid and Organ-on-a-chip Research Day+ (WORD+) Speakers Lyle Armstrong - Newcastle University, Bilada Bilican - AstraZeneca, Adriana Buskin - Newcastle University, Maria Christophorou - Babraham Institute, Davide Danovi - Migration Biotherapeutics, Fiona Ducotterd - Alzheimers Research UK & UCL, Mark Kotter - Cambridge Stem Cell Institute & bit.bio, Nick Ktistakis - Babraham Institute, Marzena Kurzawa-Akanbi - Newcastle University, Majlinda Lako - Newcastle University, Rick Livesey - Talisman Therapeutics & UCL, Matteo Martufi - GSK, Fiona Menzies - Eli Lilly & Co, Peter Rugg-Gunn - Babraham Institute, Stefan Schoenfelder - Babraham Institute,
Text reads: News - Prizes for team behind game-changing multi-omics method to decode gene regulation. Image shows Dr Yang Wang (left) and Dr Peter Rugg-Gunn (right) shown over a data analysis plot from the scMTR-seq technique.
Text reads: News - Institute immunologists uncover new process important for antibody diversity. Image shows a computer illustration of antibodies, showing the heavy chain (red) and the light chain (blue).
Text reads: News: Institute welcomes Dr Dinis Calado as a senior group leader in the Immunology programme. Main image (left) shows Dinis Calado. Two images on the right are 3D confocal images of mouse bone marrow showing plasma cells (antibody producing cells; in red), endomucināŗ vasculature (green), immunoglobulin (white), and cell nuclei stained with DAPI (blue). Credit: Abdouramane Camara, Immunity & Cancer Laboratory, The Francis Crick Institute.
Abstract background representing network connections. Text reads: News - UK Proteostasis Network receives BBSRC Network Grant.
Image shows four parallel practical workshop sessions taking place in the Babraham Instituteā€™s Flow Cytometry facility during the Spectral Flow Cytometry Symposium. Text reads: News - Instituteā€™s Spectral Flow Cytometry Symposium provides a winning blend of insights and interaction.
Photo of Tomasz on a stylised background. Text reads: Blog: A scientist in the business world - my PIPS placement with the Knowledge Exchange team. Article written by Tomasz Drobkiewicz, PhD student, University of Leeds.
Dr Theresa Pankhurst, Research Fellow at the Babraham Institute with Dr Tama Braithwaite-Westoby, Malaghan Institute of Medical Research.
Onscreen text reads: Take a 360o tour of our animal facility: Step 1: Visit. Step 2: Pick your route/area of interest. Step 3: Explore! Step 1: Visit: Orientate yourself with some information about animal research at the Institute or use this later to put in context what you see during the tour. Step 2: Your route: Jump into the areas that most interest you or follow a recommended route. Step 3: Explore: Use information buttons to learn more about what you see and key aspects of animal care.
A ball of cells dividing as the mouse embryo develops, the cells are outlined in grey and 'pop' apart to make two new cells. The size of the embryo remains fairly constant.
Dr Simon Andrews, Head of Bioinformatics at the Babraham Institute, holding a certificate and an award for the 2025 Papin Prize for Contribution to Research. Image courtesy of The UK Institute for Technical Skills and Strategy. Photography by Alex Wilkinson Media.
The Thermo Orbitrap Astral mass spectrometer, showing the sample introduction point for mass spectrometry analysis. Text reads: News - Mass spectrometry capabilities boosted by new high-throughput instrument.
A glass bowl full of skittles packets
Headshot of Simon Cook set over a background of shelves filled with glass lab bottles. Text reads: Adapting to change and challenge. Quote reads: When you stop doing discovery bioscience, the pipeline stops. So I remain an evangelist for discovery research."
Photo of Della David against an abstract background. Text reads: The rist and rise of proteostasis, with a quote by Della: "We are at a criticial moment to bring the community together and realise its potential."
Images show uveal melanoma cells showing the accumulation of lipid droplets in the absence of CDS2 (right), compared with cells with functional CDS2 (left). Lipid droplets are stained green with BODIPYā„¢ 493/503. Image from Chan et al., Nature Genetics.
Text reads: News - Signalling pathway research helps discover a new drug target for aggressive eye cancer. Images show uveal melanoma cells showing the accumulation of lipid droplets in the absence of CDS2 (right), compared with cells with functional CDS2 (left). Lipid droplets are stained green. Image from Chen et al., Nature Genetics.
Text reads: News: First in-patient treatment received for life-threatening immunodeficiency syndrome. Images: Trio of images on a blue background. Left: the protein structure of PI3-Kinase delta in complex with a regulatory subunit and a bound inhibitor. Main image: Mary and her father Jimmy Catchpole with Dr Anita Chandra at Addenbrookeā€™s Hospital. Right: Leniolisib (Joenja). Middle and right image: both by Mel Yeneralski Media Studio. Copyright Cambridge University Hospitals.
ARMA certificate and awards for Research Culture in Research Management photographed outside the Babraham Institute lab building. Certificate text reads: The Research Culture in Research Management award celebrates a project or initiative that has made a significant and positive impact to research culture, identifying challenges and opportunities and their resolution and enhancing the current culture across their organisation, sector or research ecosystem. Winner: The Institute Culture Consultation, Babraham Institute. Perspex award: visible text reads: ARMA Award for Research Culture in Research Management. The Institute Culture Consultation, Babraham Institute.
Series of slides displaying the following research questions and aims with supporting graphics: Question: How what we eat affects the activity of our genes. Outcome: Insight on controlling metabolite availability to support healthy ageing. Question: Understanding the molecular basis for an increased susceptibility to disease with age. Outcome: New healthcare approaches to treat cancer and age-related metabolic diseases such as diabetes. Question: How biological timing is encoded in the genome. Outcome: Insight on how to alter biological timings and application in regenerative medicine.
Aurora, with black hair in a ponytail, sits at a large computer screen with microscopy images of a fly gut in red in front of her.
Francesca in a blue suit next to the Italian, EU and University flag with her presentation on a display screen behind her
Video showing highlights of achievements from the Institute's Technical Specialists and quotes emphasising the important of their contributions. No audio.
Representative images of sections (from L-R) of the lung, liver, and small intestine from control (upper panel) and knockout mice (lower panel). The arrows indicate accumulation of immune cells into these tissues. Text reads: News - Maintaining balance in the immune system.
Portrait of Paul Workman and event details copied from the website - 1-2pm, 12th June, Petersfield Lecture Theatre, Babraham
Two polaroid-style images over a background of confetti. The image on the left shows Rachael accepting her award. The images on the right shows the award. Text reads: Congratualtions Rachael! Highly Commended: Researcher of the Year 2025. Cambridge Independent Science and Technology Awards
An animal technician holds a mouse in gloved hands. Text reads: News - Instituteā€™s Leader in Openness status retained for transparency around animal research
Phill Hawkins and Len Stephens with Babraham Hall in the background
Figure show a stepwise model for supporting change within a core facility, featuring headlines and further explantory text. Step 1: Establish the sense of urgency. Step 2: Create guiding coalition. Step 3: Develop a vision and strategy. Step 4: Address cultural issues. Step 5: Manage the transition. Step 6: Sustain momentum.
A group of 8 people gathered together outside with a backdrop of the Babraham Research Campus. From left to right: Phill Hawkins, Peter Cullen, Robin Irvine, Peter Parker, Roger Williams, Len Stephens and Bob Mitchell.
Len Stephens (shown left) and Phill Hawkins (shown right) with a background depicting colourful fish lures.
Microscopy images of the germinal centres in the lymph node and the lung tissue
Tuesday 29th April, 1-2pm, Babraham Research Campus. Portrait of Prof Jason Chin, on a blue background
Text reads: News - Dr Len Stephens awarded the Morton Lecture Prize. Main image shows Len Stephens with three images associated with his research area: Front image (left): Image of epithelia cells in the mouse prostate from a PTEN knockout mouse with red, orange and yellow cells showing early stages of tumour growth. Second image (top right): A section of a painting representing PI3K signalling as an electric circuit in the cell. Backmost image (bottom): Prostate tissue from a PTEN-knockout mouse stained to show hyperactive PI3K signalling.
2nd B Cell Summer School graphic, 7-10 July 2025, Lohr am Main, Germany. Graphic lists invited faculty and scientific organisers.
Baptiste and one of presentation slides: From Deficits to Strengths: How Neurodiversity changes the narrative.
Text reads: News - Institute's animal facility retains AAALAC accreditation. Image shows a mouse in a plastic tunnel being held by gloved hands.
Image shows Danielle. Text reads: Danielle Hoyle, Head of Research Operations and Deputy Director of Operations. Babraham Institute Exterprise Non-Executive Directorship.
Photo shows Hanane accepting her award from Prof. David Weinkove, President of the British Society for Research on Ageing. Text reads: Hanane Hadj-Moussa, Marie Skłodowska-Curie Fellow. British Society for Research on Ageing Korenchevsky Prize.
Photos shows Laura holding a pipette. Text reads: Laura Durrant, Genomics specialist and Technician Commitment lead. Herschel Programme for Women in Technical Leadership.
Image shows Juliet. Text reads: Juliet Emery, Head of science technical services. Herschel Programme for Women in Technical Leadership.
Image show Megan. Text reads: Megan Hamilton, Genomics facility manager. Herschel Programme for Women In Techncial Leadership.
Image shows Theresa Pankhurst. Text reads: Theresa Pankhurst, Honorary research fellow. Te Niwha Infestious Diseases Platform Kia Niwha Leader Fellow
Image shows Aljona. Text reads: Aljona Kolmogorova, Entrepreneurial Lead. Innovate UK Innovation-to-Commercialisation of University Research (ICURe) Explore Fellow
Image Maha. Text reads: Maha Ashraf, Knowledge Exchange and Commercialisation Officer. LifeArc Knowledge Transfer Innovation Fellow.
A student using a pipette wearing a lab coat and purple gloves
Text reads: News - Babraham Institute Enterprise welcomes four new Non-Executive Directors to its Board. Images: Collage of 7 images on the left hand side illustrating the Instituteā€™s research and featuring the Institute logo, with 5 images on the right hand side showing the Babraham Institute Entreprise logo and the headshots of the four new members of the BIE Board.
Text reads: The ability of cells in early human embryos to become more specialised does not depend on a process previously thought necessary from work in stem cell models.