Fred Hutch Basic Sciences Division

@basicsci.fredhutch.org

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Making Foundational Discoveries @fredhutch.org fredhutch.org/basicsciences

Please join us today in celebrating Jesse Bloom, Susan Parkhurst, and Toshi Tsukiyama for their recent awards with coffee and pastries on Tuesday, May 26th at 11am in the Weintraub Atrium! Jesse Bloom National Academy of Sciences Susan Parkhurst 2025 Fellow of American Association for the Advancement of Science Toshio Tsukiyama David and Deborah Lycette Endowed Chair for Cancer Research *Coffee and treats provided* Looking forward to seeing you there!
the last Friday Afternoon Seminar (FAS) of the 2025/26 season, this Friday 5/15 at 4pm in Pelton. Yulong Su, Eisenman Lab Multiplexed and combinatorial mapping of MYC-MAX-MGA transcription factor network in 3D Genome Joy Chen, Nabet Lab Targeted degradation of translation initiation factor eIF1A
We will be having our twenty-seventh annual Harold M. Weintraub Graduate Student Award Symposium this Friday, May 8th in Pelton Auditorium.
Friday Afternoon Seminars (FAS), this Thursday 5/7 at 4pm in Pelton. Saket Mishra, Hahn Lab How Transcription Factor Assemblies Determine Regulatory Specificity Across the Yeast Genome Rasika Venkataraman, S. Lee Lab Somatic DDX41 mutations drive myeloid malignancy through aberrant splicing of SEPTIN7
TODAY for a Basic Sciences Division guest seminar presented by Dr. Richard Sever from openRxiv. Richard Sever, PhD Chief Science & Strategy Officer openRxiv Title: “Preprints: communicating at the speed of science” 11:30am on Wednesday, May 6, 2026 B-suites (B1-072/074/076), Weintraub Building, Fred Hutch
Current Biology Seminar presented by Dr. Roberts, Lumen Bioscience. Dr. Roberts’s seminar is hosted by the Division of Basic Sciences. Jim Roberts, PhD Founder and Chief Scientific Officer Lumen Bioscience Title: “Democratizing Biologic Drugs” 12:00pm on Tuesday, April 24, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Benjamin Deneen, PhD Professor and Dr. Russell J. and Marian K. Blattner Chair Department of Neurosurgery Stem Cells and Regenerative Medicine (STaR) Center for Cell and Gene Therapy Director, Center for Cancer Neuroscience Baylor College of Medicine Title: "Glial Control of Brain Circuits and Brain Tumors" 12:00pm on Monday, April 27, 2026 Pelton, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 4/24 at 4pm in Pelton. Ishita Joshi, Tsukiyama Lab How does Quiescent chromatin affect DNA damage response? Yeon Soo Kim, Hsieh Lab tRNA directs prostate cancer lineage plasticity and therapy resistance
Members of the Basic Sciences Admin Team
Current Biology Seminar presented by Dr. Hayashi, University of Washington. Dr. Hayashi’s seminar is hosted by the Division of Basic Sciences. Marito Hayashi, PhD Assistant Professor Department of Neurobiology and Biophysics University of Washington Title: “The sensory and cellular origins of gut-to-brain signaling” 12:00pm on Tuesday, April 21, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 4/17 at 4pm in Pelton. Barry Stoddard, Stoddard Lab Caveat emptor: predicting and modeling protein-DNA recognition and binding via machine-learning computational approaches Faith St. Amant, Tapscott Lab DUX4-induced retroviral genes & the secretion of viral-like particles
Current Biology Seminar presented by Dr. Carroll, University of Washington. Dr. Carroll’s seminar is hosted by the Division of Basic Sciences. Jeff Carroll, PhD Investigator Brain Health Accelerator Allen Institute Associate Professor Department of Neurology University of Washington Title: "An update on Huntington’s Disease, the world's most curable incurable brain disorder” 12:00pm on Tuesday, April 14, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Basic Sciences Lab Guest Seminar TODAY presented by Dr. Murray from Harvard University. Andrew Murray, PhD Department of Molecular and Cellular Biology Harvard University Title: “Beyond FanDuel: Bet Hedging in the Brewer’s Yeast” 12:00pm on Monday, April 13, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch Hosts: Biggins & Malik labs
Friday Afternoon Seminars (FAS), this Friday 4/10 at 4pm in Pelton. Caitlyn Fain, Parkhurst Lab Innexins function as hemichannels in cell wound repair Alex Doan, MacPherson Lab Glyco-immunology: targeting cancer glycans as novel immunotherapy
Current Biology Seminar presented by Dr. Mitchell, University of Washington. Dr. Mitchell's seminar is hosted by the Division of Basic Sciences. Patrick Mitchell, PhD Freeman Hrabowski Scholar Howard Hughes Medical Institute Assistant Professor Department of Microbiology University of Washington Title: "Effector-triggered immune responses in antiviral defense and pathogenesis" 12:00pm on Tuesday, April 7, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 4/3 at 4pm in Pelton. Pralaksha Gurung, Singhvi Lab Glia molecular microdomains regulate multi-sensory processing Julia Walker, Holland Lab When Therapy Almost Works: Lessons from Pediatric Gliomas
Friday Afternoon Seminars (FAS), this Friday 3/27 at 4pm in Pelton. Sydney McGuire, Lapointe Lab Gatekeeping translation through a codon-sensitive conformational switch Taiki Abe, Berger Lab Loss of ESRP1/2 alters alternative splicing and promotes drug resistance in lung cancer
Dr. Susan Parkhusrt in the lab
Current Biology Seminar presented by Dr. Klevit, University of Washington School of Medicine. Dr. Klevit’s seminar is hosted by the Division of Basic Sciences. Rachel Klevit, PhD Edmond H. Fischer/WRF Endowed Chair in Biochemistry University of Washington School of Medicine Title: "Not all disorder is created equal: Functional disorder in Small Heat Shock Proteins" 12:00pm on Tuesday, March 24, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
today for a Cancer Neuroscience Synergy Seminar presented by Dr. Amit, The University of Texas MD Anderson Cancer Center. Moran Amit, MD, PhD Assistant Professor Department of Head & Neck Surgery The University of Texas MD Anderson Cancer Center Title: “Nervous tumors" 12:00pm on Monday, March 23, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 3/20 at 4pm in Pelton. Sarah Tomlin, Lehrbach Lab “Dynamic proteasome regulation by ECPS-1/ECPAS" Sahana Kuthyar, Mayers Lab "Oxygen-dependent metabolism as a mechanism for secondary pneumonia development"
Current Biology Seminar presented by Dr. Globig, Allen Institute for Immunology. Dr. Globig’s seminar is hosted by the Division of Basic Sciences. Anna-Maria Globig, PhD Assistant Investigator Allen Institute for Immunology Title: "Sympathetic nerves regulate T cell differentiation" 12:00pm on Tuesday, March 17, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 3/13 at 4pm in Pelton. Sarah Huang, Setty Lab SingleCept: A receiver-centric view of cell-cell communication Kyusik Kim, Collisson Lab FEver Dreams: Exploring iron biology in PDAC
Dr. Gottschling, Calico Life Sciences LLC. Dr. Gottschling’s seminar is hosted by the Division of Basic Sciences. Daniel Gottschling, PhD Distinguished Fellow Calico Life Sciences LLC Title: "Disentangling the complexity of cellular aging: It’s complicated…"
Friday Afternoon Seminars (FAS), this Friday 3/6 at 4pm in Pelton. Yihua Zhu, Smith Lab Conformational changes in E. coli RecBCD helicase/nuclease during DNA break repair Serwah Danquah, Sullivan Lab Replication stress as a therapeutic vulnerability in SDH-deficient cancers
Current Biology Seminar presented by Dr. Alvarez, Fred Hutch. Dr. Alvarez’s seminar is hosted by the Division of Basic Sciences. James Alvarez, PhD Associate Professor Public Health Sciences Fred Hutch Title: "Between Therapy and Relapse: The Hidden Life of Persistent Cancer Cells" 12:00pm on Tuesday, March 3, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 2/27 at 4pm in Pelton. Xuhui Jin, Adeyemi Lab SCAI at the crossroads of fork protection and replication stress Niyati Rodricks, Salama Lab Investigating the interplay between bacterial and host factors associated with Helicobacter pylori-driven inflammation
Top row, left to right: Keene Abbot, Gabriella Chua, Lifei Jiang, Won Jun Kim, Ruchita Kothari and Ayush Midha. Bottom row, left to right: Rohith Rajasekaran, Yusha Sun, Andrea Terceros, Wendy Valencia Montoya, Zachary Walsh and Peter Yoon.
Top row, left to right: Keene Abbot, Gabriella Chua, Lifei Jiang, Won Jun Kim, Ruchita Kothari and Ayush Midha. Bottom row, left to right: Rohith Rajasekaran, Yusha Sun, Andrea Terceros, Wendy Valencia Montoya, Zachary Walsh and Peter Yoon.
Genetics Society of America Mentorship Award for excellence in contributions to the mentorship of geneticists Irini Topalidou Fred Hutchinson Cancer Center
Current Biology Seminar presented by Dr. Lacy-Hulbert, Benaroya Research Institute. Dr. Lacy-Hulbert’s seminar is hosted by the Division of Basic Sciences. Adam Lacy-Hulbert, PhD Director Center for Systems Immunology Benaroya Research Institute Title: "Integrins and Internalization – promoting tolerance and resilience against attack"
Friday Afternoon Seminars (FAS), this Friday 2/20 at 4pm in Pelton. Riku Yasutomi, Moens Lab Developmental mechanisms underlying facial motor neuron diversification Mohamed Adil, Haffner Lab Decoding gene expression from cell-free DNA methylation
Gaurav Bhardwaj, PhD Assistant Professor Department of Medicinal Chemistry Institute for Protein Design University of Washington Title: "AI-enabled peptide design for diverse structures and functions" 12:00pm on Tuesday, February 17, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Nobuhiko (Nobu) Hamazaki, PhD Assistant Professor Department of Genome Sciences Department of Obstetrics & Gynecology Institute for Stem Cell & Regenerative Medicine University of Washington Brotman Bay Institute for Precision Medicine Seattle Hub for Synthetic Biology Title: "Reconstitution of mammalian life cycle in vitro" 12:00pm on Tuesday, February 10, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 2/6 at 4pm in Pelton. Heather Borror, Subramaniam Lab Systematic Investigation of Regulators of Codon Optimality Andrew Brane, Collisson Lab Parsing the direct and downstream effects of LIF – a potent effector of the tumor microenvironment
Sudarshan Pinglay, PhD Assistant Professor/Independent Research Fellow Department of Genome Sciences, University of Washington Seattle Hub for Synthetic Biology Brotman Bay Institute Title: "Shuffling, Writing, and Augmenting Mammalian Genomes" 12:00pm on Tuesday, January 27, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 1/23 at 4pm in Pelton. Mehedi Hassan, Buck Lab Exploring neurotropic virus spread from the nose to the brain Rashmi Mishra, Hsieh Lab Therapeutic targeting of eIF4E cap-binding domain reveals control of lineage fate in prostate cancer
Dr. Trapnell’s seminar is hosted by the Division of Basic Sciences. Cole Trapnell, PhD Professor Department of Genome Sciences University of Washington Title: "AI-assisted Developmental Genetics" 12:00pm on Tuesday, January 20, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Jesse Zalatan, PhD Professor Department of Chemistry University of Washington Title: "Gene regulation in bacteria and eukaryotes with synthetic CRISPR-Cas systems" 12:00pm on Tuesday, January 13, 2026 Pelton Auditorium, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 1/9 at 4pm in Pelton. Kami Ahmad, Henikoff Lab Gas and brakes for chromatin duplication Wei Li, Berjona Lab Selective ubiquitination and programmed mitochondrial disruption instruct stem cell fate choice
Dr. Toshio Tsukiyama
Group of people celebrating the retirement of Katrina Akioka.
Friday Afternoon Seminars (FAS), this Friday 12/5 at 4pm in Pelton. Changkun Hu, Biggins Lab Direct observation of interdependent and hierarchical kinetochore assembly Haolong Li, H. Li Lab Using CRISPR screens to define prostate cancer biology and therapeutic targets
Bobblehead of Aida de la Cruz
Friday Afternoon Seminars (FAS), this Friday 11/21 at 4pm in Pelton. Gardenia Sanchez, Arimura Lab Cryo-EM analysis of native protein complexes in Xenopus laevis egg extracts Saurabh Verma, Nelson Lab Investigating AR bypass signaling mechanism in castration resistant prostate cancer (CRPC)
Friday Afternoon Seminars (FAS), this Friday 11/14 at 4pm in Pelton. Edgar Fernandes, Talbot Lab Neuronal control of intestinal type 2 immune response to helminths Supriya Amonkar, Galloway Lab E2F1-3 activate Merkel Cell Polyomavirus early gene transcription and replication
Friday Afternoon Seminars (FAS), this Friday 11/7 at 4pm in Pelton. Alina Lorant, Koch Lab Microbiota educate early-life myeloid cells to promote tolerance in the intestine Naomi Yamamoto, Kugel Lab HMGA2 regulates fibroblast polarization and immunosuppression in pancreatic cancer
William Stafford Noble, PhD Professor Department of Genome Sciences University of Washington Title: "Foundation models for 3D genome architecture and tandem mass spectra" 12:00pm on Tuesday, October 28, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch
Here’s what you need to know: • DATE: Friday, October 24th • TIME: 4pm (no Friday Afternoon Seminar this day) • LOCATION: Double Helix • PRIZE CATEGORIES: Most Artistic, Horrific, Scientific, Humorous • WINNERS will be announced at the event at 5pm!
Friday Afternoon Seminars (FAS), this Friday 10/17 at 4pm in Pelton. Xiaohui Ju, Bloom Lab Determinants of human versus mosquito cell entry by the Chikungunya virus envelope proteins Matthew Chan, Campbell and Subramaniam Labs From Atoms to Action: The Biophysics of Start Codon Selection
Current Biology Seminar presented by Dr. Ring, Fred Hutch. Dr. Ring’s seminar is hosted by the Division of Basic Sciences. Aaron Ring, PhD Associate Professor Translational Science and Therapeutics Division Fred Hutch Title: "Decoding the autoantibody reactome " 12:00pm on Tuesday, October 14, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch
Friday Afternoon Seminars (FAS), this Friday 10/10 at 4pm in Pelton. Pravrutha Raman, Malik Lab Beyond histone mimicry: evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals Christian Loyo, Salama Lab Adaptive benefits of mobile genetic elements in bacteria
Eric Holland, MD, PhD Senior Vice President and Director Human Biology Division Fred Hutch Title: "Big data visualization and mouse models of cancer" 12:00pm on Tuesday, October 7, 2025 Pelton Auditorium, Weintraub Building, Fred Hutch