The Brigant Lab

@brigantlab.bsky.social

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Welcome to BrigantLab! 🧬🧪🔬 Where science meets innovation in action! ✨ 🔗 Inside The Brigant Lab : https://linktr.ee/brigantlab

DNA and RNA are two essential molecules that carry and use genetic information, but they have different roles. **DNA** is the cell's long-term blueprint, storing the genetic instructions needed to build and maintain bodies functions. **RNA** acts as the messenger, carrying and translating those instructions so cells can produce the proteins they need. #AcademicSky #ScienceSky#InsideBrigantLab #RNA #DNA
Them: “Hey, writing papers will be fun!” 🤩 Covidence Boss enters the chat👀😎 Me: Still #4,859 studies to finish … 🫠😭 #behindbrigantlab #LabLife #AcademicLife
🇳🇴Throwback to an inspiring few days at the COST Action Training School on HDR & AAV-based delivery technologies! 🧬 Thanks to the organizers, Nobel Laureates May-Britt & Edvard Moser for an inspiring exchange, and the Kavli Institute for hospitality. ✨ #GenEHumDi #CRISPR #AAV
🚨New Publication! 🚨 Our latest paper identifies CD5L as a potential target in osteoarthritis (OA). We found that CD5L levels are higher in OA patients, and reducing its expression helps chondrocytes survive in vitro. 🧬 Huge thanks to our amazing team: Kashif Rasheed, Carolina Gómez Ortega, Erlend Tande, Shiquan Sun, Xuzhao Bian, & Victor Boyartchuk. 👏 Huge thanks to our co-authors :Kashif Rasheed, Carolina Gómez Ortega, Erlend Tande, Shiquan Sun, Xuzhao Bian, & Victor Boyartchuk. 👏 🇨🇳 Special thanks to our collaborators in China, whose partnership was instrumental in strengthening the association between increased CD5L expression and the inflammatory OA endotype! 🔗 Read the full study here: https://www.oarsiopenjournal.com/article/S2665-9131(26)00107-X/fulltext #Osteoarthritis #MolecularMedicine #CartilageHealth #OpenScience
Kicking off the Training School on homology-directed repair & AAV delivery technologies at the Kavli Institute for Systems Neuroscience in Trondheim, Norway 🇳🇴 (June 24-26). @kavlintnu.bsky.social
Excellent lecture by Prof. Magnar Bjørås at NTNU. A strong reminder that meaningful collaboration with patient communities is the anchor for deep research and impactful innovation. Here: childhood dementia and rare genetic disorders. #ScienceSky #MedicalResearch #NTNU #BrigantLab
A portal to the invisible A microscope is more than a tool—it’s a way to connect what we see to what actually happens at the cellular level. This is where questions start to become answers. Where we move from what is happening to how it unfolds. #InsideBrigantLab #Microscopy #SciComm #BiomedicalResearch
Excited to share BrigantLab’s contribution as authors of **Chapter 169 on MULIBREY nanism** in *Evolving Atlas of Clinical Syndromes: From Symptoms to (Rare) Diseases*. This chapter explores the **clinical spectrum, genetics, and pathophysiology** of this rare **TRIM37-related disorder**, with the aim of improving recognition, understanding, and diagnosis of complex multi-system conditions. We are grateful to contribute to a resource designed to support clinicians, researchers, and the wider rare disease community in advancing knowledge and patient care. #BrigantLab #RareDiseases #MULIBREYNanism #TRIM37 #ClinicalGenetics #MedicalResearch
En caption ce message (seulement en anglais): 🌟 May is EDS & HSD Awareness Month! 🌟 Today it’s May! That means, it's Ehlers-Danlos Syndromes (EDS) and Hypermobility Spectrum Disorders (HSD) Awareness Month! 🦓 . 🌐 Every May, the EDS&HSD global community unites to raise awareness, share experiences, and drive progress for millions affected by EDS and HSD.⁠ ⁠. Let’s come together to make the invisible visible. 💪✨ . 💡 What can you do? . ✅ Learn about EDS & HSD. ✅ Share information and amplify awareness online. . No matter where you are in the world, you can take part, raise your voice, and support this incredible community.🧡✨ . . Together, we can create real change. 🌟🦓💙 . #ehlersdanlossyndromes #Zebrastrong #EDSandHSDawarenessmonth #EDSCommunity #BrigantLab
We’re proud to share that BrigantLab—represented by Davina and Benjamin—has joined the European Regional Task Force on Rare Diseases. 🧬🌍 . People living with rare diseases across Europe still face major challenges, from delayed diagnosis to unequal access to care. Led by EURORDIS and Rare Diseases International, this initiative brings together experts and advocates to help drive meaningful change. . We look forward to contributing our expertise to the European Blueprint for Rare Diseases, supporting stronger and more coordinated action at both European and global levels. . The Blueprint will be presented at the European Conference on Rare Diseases and Orphan Products 2026 in Prague in June 2026. . 🔗 Learn more: https://go.eurordis.org/Blueprint . #RareDiseases #Research #BrigantLab #EURORDIS #ECRD2026 #Science #Healthcare #Innovation
Yesterday at #EULAR2025, we explored Ehlers-Danlos syndrome (EDS): its diagnosis, pathways, therapies, and comorbidities. Inspiring insights into this complex condition! 🦓🌍💡✨ #EULAR2025 #EDS #ehlersdanlossyndrome #rheumaticdiseases #brigantlabonthemove #BehindBrigantLab #MedSky #AcademicSky
Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬 #EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky
🌟 Inside Brigant Lab : The chondrocytes cells 🌟 Have you ever wondered how aging cells contribute to joint damage? Let’s dive into the science together! 🧠💡 Meet the chondrocytes, the architects of cartilage health, maintaining its structure and function. But in osteoarthritis (OA), their balance is disrupted. These cells start contributing to cartilage breakdown, driving joint degeneration. As they age, chondrocytes lose their ability to repair cartilage and produce proteins that accelerate its destruction—worsening joint damage and fueling the progression of OA. Understanding their role is key to unlocking new treatments. 🧬🦴✨ Image: Chondrocyte cells in 2D culture Want to know more? Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our research and an exclusive preview of what’s next in our scientific journey. 🔍 #CellularBiology #chondrocyteresearch #osteoarthritis #science #research #ArthritisAwarenessMonth #MolecularMedicine#sciencecommunication#lablife #brigantlab #insidebrigantlab
🌟 Welcome to InsideBrigantLab! 🌟 In this series, we’ll take you behind the scenes of our lab’s journey to advance diagnostics and develop innovative treatments for rheumatologic diseases.🔬💊📖 Our first feature focuses on Osteoarthritis (OA), the most common form of arthritis—a condition that wears down joint cartilage over time. Think of cartilage as the cushion between your joints. In OA, that cushion wears thin, leading to pain and stiffness. OA affects millions worldwide and significantly reduces quality of life. 🦴♿ Did you know that by 2050, 1 in 3 people may be living with OA? Understanding its symptoms, prevalence, and the current limitations in treatments is crucial for driving innovative research. 💡 While prevention strategies exist, effective disease-modifying treatments remain a significant unmet need—and this is where our work comes in. At BrigantLab, we’re diving deep into the molecular mechanisms of OA, with a special focus on the role of chondrocytes and connective tissues.🧬🩺 Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our work, the impact we strive to create, and an exclusive preview of what’s next in our scientific journey. Have questions or topics you’d like us to explore? Let us know! 😊 #osteoarthritis #osteoarthritisawareness #rheumaticdisease #chondrocyteresearch #molecularmedicine #research #sciencecommunication #BrigantLab #InsideBrigantLab
💚 May is Arthritis Awareness Month! 💚 Arthritis Awareness Month is a global initiative to raise awareness about the impact of rheumatic and musculoskeletal diseases (RMDs), which affect millions of lives worldwide. 🌍 At Brigantlab, we’re shining a light on osteoarthritis (OA)—a common form of arthritis that impacts joints like the knees, hips, and hands. For those living with OA, chronic pain, stiffness, and reduced mobility are daily challenges.🦵🤲 For over 500 million people, OA means chronic pain, stiffness, and reduced mobility, but together, we can make a difference. 💥 🔬 Our research dives deep into how chondrocytes (the cells in cartilage) respond under pathological conditions. With every discovery, we’re closer to better diagnosis, treatments, and hope for those affected.🧬 Let’s remember: ✅ OA doesn’t discriminate—it can affect anyone, at any age. ✅ It’s life-changing, but through awareness and innovation, we can fight back. ✅ Research is the key to unlocking a better future. Join us this month to raise awareness and support advancements in arthritis research. Together, we can take steps toward a pain-free future! 🔥💚✨ #arthritisawarenessmonth #supportarthritis #EULAR #eularadvocacy #osteoarthritis #osteoarthritsawareness #chondrocyteresearch #scienceforchange #research #brigantlab
🚨 Exciting Research Update! 🚨 We’re thrilled to announce the publication of an important and exciting study in Non-Coding RNA Research where BrigantLab was part ! 🎉 We reveal a strong link between uremic toxin levels and the microRNA miR-223 in chronic kidney disease (CKD)-associated anemia. We demonstrated that the uremic toxin indoxyl sulfate (IS) increases miR-223 expression in both human erythroid cell lines and primary cells. In a cohort of over 500 CKD patients, serum miR-223 levels correlated with IS and other uremic toxins, as well as with markers of endothelial dysfunction and anemia severity. 🧬 Why is this important? These findings position miR-223 as a promising biomarker for monitoring CKD-related anemia and vascular complications—opening the door to more personalized and non-invasive diagnostic strategies. 💡 A huge congratulations to Laurent Metzinger for spearheading this important work, and to all the incredible co-authors: Emma Brisot, Pierre-Marie Leprêtre, Eya Hamza, PhD, MBA, Ophelie Fourdinier, Hakim Ouled-Haddou, Gabriel Choukroun, Ziad Massy, Francis Verbeke, Valérie Metzinger-Le Meuth, and Griet Glorieux! ✨ 🔗 Read the full article here: https://doi.org/10.1016/j.ncrna.2025.04.009 [or link in bio] 📖 Stay tuned for more updates from BrigantLab ! 🚀 #ckd #chronickidneydisease #chronickidneydiseaseawareness #anemia #BiomarkerDiscovery #mir223 #uremictoxins #nephrology #Research #Researchpapers #science #lablife #brigantlab
👋🔬 "Behind the BrigantLab" series - Meet the Minds Behind BrigantLab! Today, let's spotlight Dr. Benjamin Brigant, researcher at NTNU in Trondheim, co-founder and a driving force of BrigantLab ! Currently based at the Norwegian University of Science and Technology (NTNU) in Trondheim, Benjamin brings over 9 years of expertise in molecular and cellular biology to the forefront of our research. 💡 His journey spanned studying studying microRNAs in France (UPJV), pioneering CRISPR-Cas13 RNA targeting in Canada (UoA, Alberta), and exploring CD5L in Norway (NTNU). Now, at BrigantLab, Benjamin’s work bridges his diverse experiences in inflammation and cartilage biology. His focus includes osteoarthritis, joint disorders, and rare genetic conditions like MULIBREY nanism and Ehlers-Danlos Syndrome, with a special emphasis on joint, cartilage, and inflammation abnormalities. 🧬💪 🌍 His passion for discovery is matched only by his enthusiasm for connecting ideas across disciplines—whether in the lab or at collaborative works. ✨ Fun fact: When he’s not in the lab, you might find him hitting the snow ❄️ and cross-country skiing 🎿 during the winter months! 👉 Follow us for more behind-the-scenes moments, research updates, and a peek into life at BrigantLab! 🦓 Don’t forget, you can support our latest project: https://gofund.me/15cbe96b 🔗 Visit our Linktree in bio to learn more! #BehindBrigantLab #meettheteam #brigantlab #science #research #supportscience #lablife #skiingscientists
Wonder what goes on behind the scenes at BrigantLab? 🤔 . Our research dives deep into the mysteries of connective tissue disorders, with a special focus on: 🦠 Understanding the molecular factors in osteoarthritis 🧬 Investigating genetic diseases like Ehlers-Danlos syndrome 🔎 Exploring chondrocyte biology under pathological conditions . From understanding the root causes to delivering tangible benefits, we aim to translate lab discoveries into hope for patients in the clinic. ▶️ Watch to learn more about our passion and work! . ✨ Don’t forget, you can support our latest project: https://gofund.me/15cbe96b . 🔗 Visit our Linktree in bio to learn more! . #cellularbiology #osteoarthritis #ehlersdanlossyndrome #science #research #lablife #InsideBrigantLab