Prof David Wraith

@cameron-wraith.bsky.social

1495 Followers 305 Following

Erstwhile immunologist still working on designing antigen-specific immunotherapies for autoimmune diseases

Immune reset plus: this figure illustrates the advantage of combining Immune Reset by B cell depletion with antigen-specific immunotherapy. ASIT with antigens delivered to tolerogenic APC can ‘switch off’ autoreactive T cells while promoting differentiation of antigen-specific regulatory T cell populations. Most importantly, ASIT approaches have been shown to function in B cell depleted animal models. Tolerance induction by ASIT depends on antigen presentation by steady state dendritic cells in lymphoid organs or by APC in the tolerogenic environment of the liver. Immune reset plus ASIT will enable disease to be controlled without continued B cell depletion. This will allow the treated individual to control infections and respond to vaccines.