Cameron Hill

@cameronhill13.bsky.social

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Postdoc in muscle biophysics at KCL using X-ray diffraction to observe regulation of contraction in skeletal muscle. Interests in ageing, obesity and exercise phys.

X-ray diffraction patterns of mouse skeletal muscle. The right picture is a difference pattern of contracting minus resting. 1,0 & 1,1 - equatorial reflections associated with the hexagonal lattice arrangement of the thick and thin filaments M3 - the third-order meridional reflection associated with the ~14.34nm axial repeat of myosin motors M6 - The sixth-order meridional reflection associated with the ~7.17nm axial repeat of the thick filament backbone M11 - The eleventh-order meridional reflection associated with the ~3.9nm axial repeat of A-band titin ML1/AL1 - The mixed first-order myosin and actin layer lines. ML1 is associated with the ~43nm helical repeat of myosin motors whilst AL1 is associated with the ~37nm helical repeat of actin helices AL2 - The second-order actin layer line associated with the azimuthal position of tropomyosin in the thin filament. This reflection is incredibly weak at rest and intensifies on contraction. AL6 & AL7 - The sixth- and seventh-order actin layer lines associated with the genetic helices of actin of axial spacing ~5.9nm and ~5.1nm respectively