TRAstonDrs

@castltrastondrs.medsky.network

10139 Followers 1837 Following

"Not all those who wander are lost" JR Tolkien #Clinicalresearcher #DrugDevelopment #Clinicaltrials & Registration 🧬🔬📚🔎🦠🧫 📌 Melbourne 🇦🇺 Oxford 🇬🇧& 🏴󠁧󠁢󠁳󠁣󠁴󠁿 #MedSky🧪

The sun that's just beaming through
2 chic who will be leaving the nest
🗽rise above the clouds
On a still warm Saturday morning, snuggled in blankets and gazing out the window, a world bathed in inviting light unfolds.
Infographic
The setting sun at 9:30 PM
Another wood pigeon net that hanging on my climbing rose and they are truly beautiful squatters
One morning in August, the sky was a brilliant red with prisms.
Beyond medicine and humanity lies the heartbeat – one morning, one capture that profoundly moves you.
As the sun breaks through, dispelling yesterday’s numbness and mindlessness.
One morning walking into Town
Dr Maria Van Kerkhove, visiting a live animal market in South East Asia.
Christmas photos
Simba, the seamstress
Coco wanted to play ⚽️ but no one was interested.
Simba ,A snoozy teddy bear
Simba from post operation
CoCo , the sheepsky and the morning run
A walk in town… Oxford 🇬🇧
Home is where healing and comforting words are shared. On a heatwave day, I was reminiscing about my favourite 📚 , Max & Coco.
Even on the hottest days, something fresh and lovely always inspires you to move on.
Diagrammatic representation of how SARS-CoV-2 Spike protein can exist in a meningeal “reservoir” where it can stimulate meningeal mast cells directly leading to subsequent activation of microglia and disruption of the BBB permitting the Spike protein to cross the BBB and activate mast cells and microglia leading to neurovascular inflammation. Designed using Canva and Gemini-AI.
Morning run
As dawn breaks take a deep breath and life continues.
Before the rain, a certain calmness settles in the soul, accompanied by a shimmering stillness reflecting off the lake.
Gazing at the morning through the lens of time, it seems to have stopped.
Radcliffe Infirmary. Universty of Oxford, 🇬🇧 https://www.oxfordhistory.org.uk/doctors/infirmary/index.html
Summary of Immune Profiles & Clinical Corelations
Fig. 1. Key innate immune drivers and self-sustaining pathological loops in PASC. Residual SARS-CoV-2 antigens, host-derived DAMPs, reactivated latent viral products, and translocated microbial components form a central hub of persistent stimuli that chronically activate innate immune pathways in PASC patients. These signals engage PRRs, the NLRP3 inflammasome pyroptosis axis, complement cascades, and neutrophil responses, including NETosis. The resulting release of pro-inflammatory cytokines, chemokines, and alarmins perpetuates self-sustaining inflammatory loops and obstructs the immunological resolution. Persistent activation further promotes maladaptive trained immunity, reinforcing innate dysregulation and driving chronic cycles of inflammation and tissue injury, distinct from the resolving trajectory of acute COVID-19. Note: This figure was created using BioRender (www.BioRender.com).
A view of dawn breaking through the window.
Glimpse through the morning sun’s rays filtering through the cobwebs.
Transmission model and risk of different human-to-human transmission modes among SFTS in China. Note: The left picture describes the 30 index patients’ exposure ways to SFTSV. All were exposed during their routine laboring related with agriculture. There are six index patients exposed to confirmed or suspected tick bites during both laboring in the hills and weeding and raising livestock in yards or their surroundings. SFTS severe fever with thrombocytopenia syndrome, SFTSV Severe fever with thrombocytopenia syndrome virus, SAR the secondary attack rate
A magical sunrise peeked through the window.
A quick run in the park after my last COVID 💉 this year.
Vaccinated Certificate
Simba the chow who snores to the moon.
Comparison of Viral Shedding Metrics
Chemical structures of Protein–protein interaction inhibitors and their antiviral activities.
Highlights
Comparison info
The honey 🐝 and it’s breakfast
Max is resting on the bench, overwhelmed with the heatwave .
In making decisions, your own mind may be your worst enemy.
Infants born to healthy mothers are more resilient to pathogen exposure and likely to grow and develop to their full potential (ideal trajectory of steady health), whereas those born to unhealthy mothers (pre-term or with low birth weight) fall into a cycle of increased susceptibility to repeat infections, growth faltering, malnutrition and death (the vulnerable trajectory). Repeated illness dramatically reduces child’s potential for physical growth, development, and quality of life. Mothers who become pregnant again (dashed arrow) initiate a repeat cycle of sustained health or vulnerability, which can perpetuate for generations.
Conceptual illustration of lipid raft organization within cellular membranes. Cholesterol (yellow) and phospholipids (blue and brown) are present in both leaflets of the bilayer, while sphingolipids (violet) are predominantly localized in the outer leaflet. Lipids in raft regions typically feature long, saturated acyl chains (violet and brown), in contrast to the shorter and more unsaturated acyl chains (blue) found in non-raft areas. Raft microdomains are enriched in proteins with dual acylation (green) and glycosylphosphatidylinositol (GPI) anchors (brown), whereas transmembrane (blue) and prenylated (green) proteins are more commonly located in non-raft regions. GPLs: Glycerophospholipids; GSLs: Glycerosphingolipids; SM: Sphingomyelin. Reproduced from [11]. Copyright by the authors under a CC BY 4.0 license.
Simba the chow needs a break from the heatwave e fan on the way
Reflection of the loch
The long unraveling “foggy” valley with the #neurocovid patients #LongCOVID patients suffer from a spectrum of neurological disorders including headache, anosmia, encephalopathy, peripheral neuropathy, and cerebrovascular events; neurodegenerative changes resembling early Alzheimer's and Parkinson's pathology
A bright nascent sunrise filters through the hazy heat of the day.
A run before the mercury rises.
The morning in delight,view from the window
Among participants who prospectively collected daily, paired specimens from multiple upper respiratory anatomical sites while enrolled in a case-ascertained COVID-19 household transmission study conducted in Los Angeles, California between September 2020 and April 2022, a subset of participants were found to initially be negative upon enrollment but later became positive for SARS-CoV-2. These were defined as Cases of naturally acquired, incident SARS-CoV-2 infection, and for whom age, sex, and prior COVID-19 vaccination status matched Control participants without SARS-CoV-2 infection were identified, and demographic data is shown. Samples underwent viral load quantification by RT-qPCR, validated by RT-ddPCR, and human transcriptome sequencing to calculate immune pathway activation and determine the timing of Type I and II IFN response initiation, and expression of a tissue resident memory T cell (TRM) signature. Differences in the magnitude and timing of these pathways were compared by vaccination status, and by subsequent viral RNA shedding to identify mucosal immune correlates of reduced viral replication. Created in https://BioRender.com.
Infographic
A red rose serves as a bookmark.
Once upon a time, in Central Station, New York.
Temporal and organ-specific regulation by transcription factors
In the blazing midday sun everything is illuminated and thriving.