Chris Miller

@chrismiller.science

2161 Followers 213 Following

I study cancer at Washington University in St Louis. Cancer Genomics, Bioinformatics, Data Viz, Tumor Evolution, AML, Immunotherapy, Irreverent humor 🧬 🖥️ mostly @chrisamiller on other platforms

US currency
Screenshot of a long read transcriptome explorer, showing YBX1 alternative splicing in SRSF2 mutant samples
I want to make a simple argument: every new bioinformatics tool and method you write should be AI-ready. AI assistants need to work with your code, your outputs, and your analysis logic. Machine learning needs to train on the rich data your tools produce. If you’re not gathering this data as you go, you’re leaving value on the table.
Plot showing how many records need to be returned to ensure that each completely typed gene will be in the list.
199 AR 120 PC 100 KL 78 ZNF7 67 ZNF2 67 CS 58 CP 58 ADA 57 SI 55 ZNF3 52 TH 51 C2 43 MAG 42 ZNF8 42 TNF 41 GPR1 37 DEFB1 36 USP1 36 GAL 34 PLEK 31 MET
Newsweek - On target - Genetic Sequencing is creating bespoke cancer cures.
Our analysis suggests that mirror bacteria would likely evade many immune mechanisms mediated by chiral molecules, potentially causing lethal infection in humans, animals, and plants. They are likely to evade predation from natural-chirality phage and many other predators, facilitating spread in the environment. We cannot rule out a scenario in which a mirror bacterium acts as an invasive species across many ecosystems, causing pervasive lethal infections in a substantial fraction of plant and animal species, including humans. Even a mirror bacterium with a narrower host range and the ability to invade only a limited set of ecosystems could still cause unprecedented and irreversible harm.
There are 50 petabases of freely-available DNA sequencing data. We introduce "Logan Search" which allows you to search for any DNA sequence in minutes, bringing Earth’s largest genomic resource to your fingertips.
Do you want to be good at science, or do you want to be good at emails?
There are 19 humans in space
Is it hot? does it look good? Are you proud to serve it?
We study how sick cells in our bodies (growing too fast) get away from the doctors trying to stop them. Sometimes the cells already know how to escape, sometimes they have to learn it, but either way, they try really hard. If we don't stop them, people with the sick cells die. Better ways to stop these cells are hard to figure out, but using different sorts of tiny pictures of the cells, we're trying. We take many many tiny pictures and then use computers to sort through and find the problems that make the cells sick. We hope we can find ways to stop the bad cells without hurting the good ones, so that people can live longer!
The weird thing about The Simpsons is that while the average quality of the jokes has decreased over time, the average quality of each individual character's jokes has actually increased over time
Aurora borealis
the secret to multi-tasking is apologizing constantly to everyone you know forever
Shipping Household Goods Inside an Ocean Container
Chris Miller I get that I'm not the arbiter of terminology but it all seems like meaningless distinctions to me. If you're using computers to study biological information, then use any combination of those words as a title, Then more importantly, tell me what you *actually do* Michael Love so you're cool with me saying I study Computeral Bioinfology Rob Patro As long as you sound drunk whenever you say it, I’d be fine with this.
Sycamore tree from below
Nobel prize awarded to Katalin Kariko and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19
Top Gun: I feel the need, the need for speed!