Clémence Marchal

@clemmar.bsky.social

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Group leader at @ipbhalle.bsky.social Plant - Microbe Interactions 🌱🦠🍄 She/her

Cartoon depicting pathogens secreting molecules in the apoplast and inside the plant cell, which can be recognised by plant immune receptors located at the plasma membrane or in the cytosol
CC-NLRs exhibit diverse conformations in the resting state. Figure depicts different NLR resting and activated states. While ZAR1 exists as a monomer bound to its guardees in its resting state, several forms have been observed for the NRC2 helper, including dimers, tetramers, and filaments. While filament-like structures were observed via confocal microscopy for NRC2 upon overexpression in planta, these structures were not detected for its paralog NRC4, suggesting a potentially different resting state configuration for NRC4. Our work suggests that the Pik CC-NLR pair forms a hetero-complex bound to the plasma membrane in its resting state. How effector binding to the integrated domain (ID) of the Pik-1 sensor leads to the activation of the complex remains to be determined.