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John Rittenhouse

@cryect.bsky.social

488 Followers 507 Following

VR Software developer for past ten years currently working at OssoVR on surgical training

Calvin and Hobbes where Calvin in the future expects his past self to have some his homework who went to the future expecting to retrieve it already done.
I ain't reading all that I'm happy for u tho Or sorry that happened
Yes, the planet got destroyed. But for a brief moment we had our norms.
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Steam Replay 2024 for Cryect. 45 games played, 415 achievements, 86% Keyboard and mouse, 9% time on Pacific Drive, 7% Against the Storm, and 7% Enshrouded
Claude chat John Why when studying the effectiveness of HPV vaccines do they only look at invasive cervical cancer and exclude stage 0 cervical cancer? The focus on invasive cervical cancer (stages I-IV) rather than stage 0 (carcinoma in situ/CIN3) in HPV vaccine studies stems from several important methodological and clinical considerations: 1. Natural History: Many stage 0 lesions regress spontaneously without treatment, especially in younger women. Including these cases could make it harder to determine the true protective effect of the vaccine since some improvements might happen naturally. 2. Clinical Significance: Invasive cervical cancer represents the most important health outcome, as it has the greatest impact on mortality and morbidity. Stage 0 is considered pre-cancer and is highly treatable with nearly 100% survival rates. 3. Time to Outcome: Stage 0 occurs relatively quickly after HPV infection, while invasive cancer typically takes 10-20 years to develop. Looking at invasive cancer provides better evidence of long-term vaccine protection. 4. Statistical Power: Including stage 0 cases could potentially dilute the statistical power to detect the vaccine's effect on preventing the more serious invasive cancers. However, many studies do look at CIN2+ and CIN3+ as secondary endpoints since these are important precursor lesions. Would you like me to explain more about how these different endpoints are used in vaccine research?
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