Centre for Structural Systems Biology CSSB

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Photo: O. Jaeckle-Tietjen
Comparing polyprotein processing in four human coronaviruses revealed distinct and common features like delayed cutting between nsp7 and nsp8. AlphaFold3 models (here SARS-CoV-2 nsp7-11) showed that this cleavage site can form a helix. The methyltransferase nsp16 binds nsp10 depending on the virus even prior release from the polyprotein. IMAGE: Kira Schamoni-Kast
3D-Animation of the nanobody (light yellow/semi-transparent) inhibiting HSV-2 glycoprotein B. The different domains of gB are color-coded. Three domains are held together by the footprint of the nanobody. IMAGE: Benjamin Vollmer / Centre for Structural Systems Biology
Group of people in front of CSSB. IMAGE: DESY/ Marta Mayer