Charlie Pugh

@cwjpugh.bsky.social

261 Followers 1171 Following

PhD candidate - Machine Learning and Genomics @CRG.eu with @jonnyfrazer.bsky.social and @MafaldaFigDias

We show a scatterplot of ROC-AUCs for each gene, calculated separating benign and pathogenic labelled variants with either usual or LFB fitness estimation
We show a plot of Model Size vs Mean Spearman Correlation across the DMS datasets from ProteinGym for ESM-2 and ProGen2 model families both with and without the LFB estimation.
We show a schematic of the LFB estimate where by averaging over predictions for a variant applied to other related sequences, we produce an score which should be closer to the true change in fitness.