Darío Lupiáñez @dariloops.bsky.social · Feb 24 5/n Our initial analyses revealed a high degree of conservation in TAD structures and moderate changes in A/B compartments. 3D chromatin structure seems to be mostly preformed before #sexdetermination occurs!
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6/n But are conventional tools for Hi-C analysis well suited to identify meaningful changes for #generegulation? How can such a minor variation in 3D chromatin organization explain a process characterized by major changes in #transcription and cell identity?