Chen Davidovich @davidovichlab.bsky.social · Mar 15 3/ H3K27me3 binds to PRC2. Some proteins mimic H3K27me3 to directly interact with the H3K27me3-binding site in PRC2. - The Margueron lab showed it for JARID2: pmc.ncbi.nlm.nih.gov/articles/PMC... - We showed it for PALI1/2: www.nature.com/articles/s41...
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4/ Why do JARID2 and PALI1/2 mimic H3K27me3? They are thought to "jump start" PRC2 in the absence of H3K27me3, to initiate H3K27me3 de novo. While this model agrees with biochemical and KO+rescue experiments in cells, it was never tested in vivo.