Elzo de Wit lab @ NKI

@dewitlab.bsky.social

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Computational & Genomics Lab studying 3D genome function and dynamics @ Netherlands Cancer Institute

Phased variants can be used to identify allele-specific ATACseq peaks, linked to allele-specific expression data.
Cartoon describing how synthetic long reads and Hi-C can be used to haplotype individuals.
CTCF depletion disrupts morphogenesis of gastruloids
Hi-C maps potentially showing fountains
scatterplots showing similarity in insulation scores
Enrichment of downregulated genes following RAD21 depletion in fountain bases. And a cartoon suggesting a mechanism.
ChromHMM enrichment heatmap showing that enhancer categories are enriched in fountain bases.
Hi-C maps directly showing the role of cohesin in the formation of fountains.
ChIPseq heatmaps suggesting that cohesin is loaded at fountain bases.
Hi-C maps and aggregate plots showing fountains in unperturbed and perturbed cells.