Anne Carpenter

@drannecarpenter.bsky.social

15500 Followers 1550 Following

Dedicated to drug discovery, enthralled by science. 5 kids. She. SAB Recursion. Founder SyzOnc. Lab at Broad Institute. Opinions my own.

call for artists July 1
mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further
Two examples of succcessful mislocalization drugs can change protein localization, as shown in cells
Images of cells showing protein mislocalization caused by a Noonan syndrome mutation, with the idea to screen drugs to find any that can reverse the unhealthy mislocalization
meme picture: i would like to save my files to the docs folder.... on my computer.... that I own... in my house
screenshot showing TUrn on AutoSave by default unchecked
Tweet, in the elevator Whose lab are you in Mine No I mean who is the PI Me No, like what professor’s lab The Columbus lab and I am Columbus
Screenshot that says my 13-year-old son told me that when he hits 99 pounds, he wants to eat 1 pound of nachos on his own so he can be one percent nacho.
OASIS logo: Omics for Assessing Signatures for Integrated Safety Consortium
sponsors for Recode Edge: Lilly, AWAS, true, JPM, DLA Piper, OpenAI, World Business Chicago
Photo of Anne Carpenter with STATus List 2025 wording
image showing escape mechanism
image showing escape mechanism
image showing escape mechanism
This is the specimen. Its dimensions are 22 mm (not counting the lateral protrusion) by 22mm.
Screen shot of the article
mini-bag full of throat lozenges labeled "Cancer Sucks. Let's Save Lives Together. SyzOnc"
PubMed search showing 102 results for the term “genome-wise”.
Image of the job posting (see URL for full text instead)
I suppose, then, I am well qualified to say something about staying in the game. I have done it for over twenty years. I have contributed to research on several topics in biology and the social sciences. I hold a full professorship in a decent research-intensive university. I get some very nice academic invitations. So it seems I have avoided the ‘exit academia’ arrows, possibly even with aplomb. But—and this is what qualifies me—I haven’t avoided them nearly as easily as you probably think. If it looks that way from the outside, that’s only because you lack the data I have. You don’t see the failures, the false starts, the wasted time, or the awkward conversations with the Dean. (These are ubiquitous, by the way, just not well written up in the literature.) And opposite the Scylla of the ‘exit academia’ arrows has always lurked the Charybdis of my own demoralization: walking away from the game even if the game does not eject me. I gave up completely once, for several years, then eventually clawed my way back in; a second time I partly gave up but left myself attached by a lifeline, a lifeline I duly climbed up within a year or so; and probably two or three more times over the years I reached the point of starting to make other plans. Periodic demoralization and depression are not rare amongst researchers. It’s not not caring any more, or not being able to be bothered, as depression is often and erroneously characterized. It is caring so much, being so bothered, that one cannot advance on any front. One drowns in one’s own disorganized and gradually souring passion. This feeling is probably near- ubiquitous too.
plot showing a cluster of INSYN1, RNF41, MYT1 (the latter being anti-correlated with the first two). None of the 3 genes are known to be related to each other per the knowledge graph.
plot showing that increased morph similarity correlates with increased likelihood the gene pair is 'known' in a knowledge graph
plots showing what sorts of genes are more likely than average to have a phenotype.
Plots showing morph similarity
Data showing Venn diagrams for genes tested and genes tested that have a phenotype for ORF, CRISPR and both
Chart from Carta showing seed preseed funding down 5-7% vs 2023, series A down 11%, while other stages are net positive vs 2023. Up 17% overall
Screenshot of a blue sky “receipt”, created by the link in the quoted post. It shows the number of posts and a few other statistics about blue sky usage for myself.
Cell Press' marketing that has a picture of Anne and her quote "Science isn't all sunshine and rainbows, so it's key to develop reslience"
word cloud based on google scholar paper titles - for Anne, it's image-based cells, imaging, profiling, high-throughput, cellprofiler
Hostess cupcake, dark chocolate with white squiggles
“Everything is fine” room on fire meme, with the text “I’m thrilled to announce my promotion to full professor”
Cartoon of man on plane with hand raised, saying “These smug pilots have lost touch with regular passengers like us. Who thinks I should fly the plane?”
Fig from paper showing a slight positive bias in image-based profile similarity for pairs of CRISPR and ORFs targeting the same gene (in two cell types)
Screenshot from the New York Times, showing races that are still too close to call and impact which party takes control of the house
My dad on a tractor, with a hat for Northern Indiana tractor enthusiasts. The tractor is green even though my favorite tractors are red because as he aged, he switched from red (the proper color, International Harvester tractors) to green and orange... *sigh* But I loved him anyway.
Two skeletons triumphantly hold rolls of toilet paper next to a tree that has been toilet papered in the yard.
Two skeletons playing a giant jenga game in the yard
Skeleton driving a toy car shoved against a tree; skeleton and police uniform leans over the car to check on the passenger, having left his little toy car behind him
Two selections do yard work
Skeletons sits on a bench, while a skeleton nearby in a yellow reflective vest holds a stop sign
Two skeletons dressed in pajamas and slippers are seated at a card table with breakfast in their front yard, reading the Boston Globe. A dog skeleton plays with a ball at their feet.
Picture of the Boston Globe article about the skeletons. The photo shows A skeleton riding a bicycle up a ramp and jumping over another skeleton on the ground.
Skeleton guards goal with a big lacrosse paddle thing, as another skeleton approaches. Three ghosts watch the sporting event in the background.
Night view of yard with two skeletons, one in a wedding dresses carrying flowers, and a third taking photos. Three ghosts nearby witness the happy occasion.
Two skeletons roast marshmallows over a campfire made of orange traffic cones and a few logs. A baby skeleton sits in one skeleton’s lap.
Skeleton in referee garb hooks a victorious skeleton’s boxing gloved hand high while a defeated skeleton with boxing gloves melts into the earth
Skeleton about to throw an axe at another standing in front of a target
One skeleton is painting another lying on a bench wearing a blue necklace
Twitter post from Ethan Mollick - papers show the migration of academic communities from Twitter mostly failed, but they never fully returned to Twitter either
Description from the article of vault structures in the cell
A plot of AWS download data, showing various spikes over the past 5 months. Some peaks are in the range of 50-250 terabytes.
" I received an email, out of the blue, from Ewan Birney, the Director of EMBL-EBI, saying ‘hello, I heard that you are doing image analysis, we have openings for group leader positions at EBI and you should apply’. I thought, no, no, no, that sounds very scary, but again, I was fortunate to have someone pushing me to try. It turned out to be a great opportunity and I started my lab there in 2018. Since then, I got involved into a couple of other projects, including leading an initiative at EMBL to promote theoretical approaches to biology. I got really excited about leading community initiatives as well as doing research, so I took on the role of Deputy Head of Research at EMBL-EBI. I then heard about exciting things around bioimage analysis happening in Zurich, and that is what brought me to the BioVisionCenter."
Anne Carpenter and a very cute kid celebrating the grand prize win for SyzOnc, holding the award
An AMC Pacer car
4 NYT headlines: The challenges of an aging president Me President, ditch the stealth about health The Q is not if Biden should step aside. It’s how. Democrats can no longer stay silent about Biden
Electronic game Simon Says
Tweet from Yann LeCun, which says “AI is not some sort of natural phenomenon that we have no control over. AI is being built by us, humans. Hence, if you’re scared of AI, what you were actually scared of are your fellow humans. You probably have doubts about the ability of institutions to do the right things with it. Why?”
Data from financial Times titled “ Americans are adamant that US economic circumstances are getting worse. They’re wrong.” 90% think prices have risen faster than wages, but they are incorrect.
Triptych of watercolor sketches of cute cells playing with paint, brightly colored
Picture of a zero G bed with head and feet raised