Eileen Parkes

@eileenparkes.bsky.social

3137 Followers 839 Following

Assoc Prof Oxford MD PhD. Oncology, early phase trials, tumour microenvironment #womenInSTEM #immunology

A sign on the left reads "Caution runners - dead slow" as some runners jog past. There's a blue sky and trees in the background.
Across independent cohorts, patients with CINhigh and myeloid-high EAC experience poor clinical outcomes
In chromosomally unstable tumors, CXCL8 expression is increased in tumor regions
Image shows cell types which correlate with increasing chromosomal instability (myeloid populations dominate) and representative images of inflamed, CINhigh tumor and a CINlow tumor
In situ measurement of cGAS-positive micronuclei really neatly correlates with orthogonal genomic measures of chromosomal instability - we include example CIRCOS plots of CINhigh and CINlow tumours showing the difference in rates of structural variants
We serially edited a Barrett's Esophagus cell line (CP-A) to make this increasingly chromosomally unstable, identifying genes which scaled with increasing chromosomal instability
Model figure of treatment induced CIN responses in wildtype and cGAS-KO cells. We found broad induction of inflammatory genes, a subset of which were cGAS-dependent
Model figure - in EAC cancers, as chromosomal instability (CIN) increases, we found that a CIN-driven cGAS-dependent axis drives myeloid directed chemokine expression and recruitment of tumor-favoring myeloid populations
A coffee mug sits on a marble surface. It has colourful yellow, orange, red and teal stripes along the bottom of the mug. Do you drink it?
View of the Radcliffe Camera Oxford
Picture of a scientist at a lab bench (the scientist is male, I am not)
Photograph of a grey heron standing still at the side of a muddy brook
A jogger smiling beside a ceramic big fish sculpture - where to next?
Your Western blot module is surrounded by talismans for good fortune. Baby Yoda x 3, a troll and a slightly lost sheep. Surely, it cannot fail you now!
Picture of Text which reads - I always thought X was something you click on to close it down. John Handford. Macclesfield, Cheshire.