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This cover highlights the article Tyrosine kinase targeting uncovers oncogenic pathway plasticity in Tasmanian devil transmissible cancers by Anna Schönbichler, Andreas Bergthaler, Richard Moriggl and colleagues. Two independent transmissible cancers have emerged in the Tasmanian devil, DFT1 and DFT2. DFT1 is driven by ERBB and multikinase signalling, while DFT2 is driven by PDGFRA. Kinase targeting reveals emerging resistance and remarkable oncogenic pathway plasticity, supporting combination treatment for more durable control. The cover illustration shows Tasmanian devils affected by DFT1 and DFT2 in a Tasmanian landscape beneath the Aurora Australis. (Cover concept by Anna Schönbichler, scientific illustration by SciStories)