Eric Schneider @ericbschneider.com · Sep 19 Vaccination, introduced in 1802, changed the landscape. As smallpox prevalence dropped, fewer people contracted it as children. In addition, the immunity granted by vaccination waned with age, so by 1820, some pregnant women were susceptible to smallpox.
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This led to a small rise in stillbirths among vaccinated women whose immunity had weakened. However, with overall smallpox rates much lower, the demographic impact remained limited.