Florian I. Schmidt lab

@fischmidtlab.bsky.social

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Cell Biology meets Immunology and Virology, spiced up with nanobodies

Postdoc positions in molecular immunology and nanobody technology in the Schmidt lab at Uni Bonn, Germany
Postdoc position in Molecular Immunology and Nanobody Technology in the Schmidt lab at Uni Bonn, Germany
Recombinant viruses encode inflammasome reporter caspase-1 CARD-EGFP and inhibitory AIM2 nanobodies, which block inflammasome assembly in macrophages, but not monocytes.
While overexpression of AIM2 PYD-EGFP assembles filaments, co-expression of AIM2 nanobodies blocks filament formation and inflammasome asssembly
Infected human primary macrophages and monocytes undergo pyroptosis and assemble inflammasomes.