FlyBase

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Curating and cataloging the world's data for the fruit fly Drosophila melanogaster into our database at http://flybase.org. Aiding discovery since 1992.

The FlyBase Downloads menu gives you access to bulk data files of our very freshest data. So many bulk data files! You can mine them with your favorite AI assistant on your own machine, and give the FlyBase infrastructure a break.
The FlyBase QuickSearch tool, open to the Human Disease tab. The tab is boxed in purple, while the link to the Human Disease Model index is circled in purple.
A FlyBase hitlist including the three most recent Human DIsease Model Reports, neurodegeneration with brain iron accumulation 5; Charcot-Marie-Tooth disease, axonal, type 2KK; and spinocerebellar ataxia 36.
The FlyBase QuickSearch tool, opened to the GAL4 etc tab. The tab is boxed in purple, while the link to the Frequently Used GAL4 And Other Binary System Drivers resource is circled in purple.
The FlyBase Frequently Used GAL4 and Other Binary System Drivers resource.
The FlyBase QuickSearch tool, open to the Pathways tab. The tabs for Gene Groups, Complexes, and Pathways are boxed in purple The links to the indexes of Signalling Pathway reports and Metabolic Pathway reports, at the bottom of the tab, are also boxed in purple.
Job Summary: The FlyBase project is an international collaboration of ~35 people distributed at several sites. This position is located at Harvard University, Cambridge, MA. All FlyBase staff work as a part of a team, in which curators and software engineers collaborate extensively. Each site has its own set of responsibilities. The Harvard FlyBase curators focus on curation/annotation of literature and high-throughput data pertaining to the Drosophila genome, transcriptome and proteome. FlyBase is constantly evolving, seeking both to improve and to expand its role within the Drosophila and wider scientific communities. The ideal applicant will be enthusiastic about participating in this process, bringing to the FlyBase group expertise and ideas concerning emerging directions in Drosophila biology and genomic/proteomic analysis. FlyBase is increasingly integrating artificial intelligence and machine learning tools into its curation workflows. The ideal candidate will be open-minded and enthusiastic about exploring AI-assisted approaches to biological data curation, including the use of large language models and AI coding assistants to accelerate and enhance curation tasks.
The award to the FlyBase development team recognized Database developers Gil dos Santos, Ian Longden, Christopher J. Tabone, and Pinglei Zhou; Web developers Seth Campbell Victor Strelets, and Jim Thurmond; System administrators Kris Broll and Mark Zytkovicz; Administrative support Carol Sutherland and Jolen Seme; and Program director Susan Russo Gelbart.
The committee for the 2026 Drosophila Community Service Award for outstanding community service included Michelle Arbeitman (Co-chair), Cale Whitworth (Co-chair), Elizabeth Chen, Lydia Grmai, Amy Kiger, and Steven Marygold.
FlyBase Funding Update – March 2026 The NHGRI funding for FlyBase has been restored for US-based FlyBase teams but the foreign subaward that supported the essential curation team at the University of Cambridge UK has been terminated. Therefore, the Cambridge UK team now requests annual contributions from fly labs to support curation of new data into FlyBase and the Alliance of Genome Resources. Without these annual contributions, FlyBase will become frozen in its current state and become progressively less useful. Please visit the ‘Contribute to FlyBase’ wiki page for details of how to contribute.
The FlyBase QuickSearch tool, with the GAL4 etc tab and the link to the Frequently Used GAL4 and Other Binary System Drivers resource circled in pink.
The Frequently Used GAL4 and Other System Binary Drivers resource filtered to show a newly added GAL4 driver.
A FlyBase Gene Report opened to the Linkouts subsection of the External Crossreferences and Linkouts section. The section heading and the FlyCyc Genes linkout have been boxed in bright pink.
Screenshot of the FlyCyc page at https://biocyc.org.
Screenshot of the path to find the Alliance of Genome Resources BLAST tool from a FlyBase page.
FlyBase Update – October 2025 The termination of the NIH/NHGRI FlyBase grant has placed the long-term sustainability of FlyBase at risk. However, thanks to the generous support of several key individuals and institutions, we are pleased to announce that FlyBase will remain operational through the coming year. We extend our deepest gratitude to Yukiko Yamashita, Cassandra Extavour, Hugo Bellen, Thom Kaufman, the Genetics Society of America / Drosophila Board, the Bloomington Drosophila Stock Center, an anonymous donor and the Wellcome Trust. We are especially thankful for a generous gift from Seemay Chou, Jed McCaleb, and The Navigation Fund. We also greatly appreciate the continued support from the broader Drosophila community – your donations and service fees have been vital in helping us stay afloat. Special thanks also go to Jessica Manning for her tireless administrative work at Harvard, to Ruth Lehmann, Hugo Bellen, and Paul Sternberg for advice and efforts, and to the Board of the European Drosophila Society for all their efforts. Sadly, we must also share that several long-standing FlyBase team members have recently moved on. We are immensely grateful to Susan Russo-Gelbart, Lynn Crosby, Gil dos Santos, Kris Broll, Victoria Jenkins, and TyAnna Lovato for their many years of dedicated service and contributions to FlyBase. Looking ahead, ensuring FlyBase’s sustainability beyond the next year – and successfully integrating with the Alliance – will require new funding sources. We kindly ask for your continued support: • European labs: Please consider contributing to the Cambridge, U.K. FlyBase group • U.S. and other non-European labs: Please consider contributing to the U.S. FlyBase groups • Both U.K. and U.S. FlyBase are working diligently to establish an invoicing system. We appreciate your continued patience. For more information on how to support us, please visit: Contribute to FlyBase wiki page https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase
A graphical overview of the results of searching D. melanogaster protein databases with the Dll-RB transcript sequence.
Screenshot of the Alliance Fly BLAST, showing the options to search D. melanogaster nucleotide and protein databases.
Screenshot of the Alliance of Genome Resources BLAST page. BLAST Service Welcome to the BLAST Service for the Alliance of Genome Resources! This BLAST service allows researchers to search genomic sequences using the Basic Local Alignment Search Tool (BLAST). By entering a sequence or query, users can find regions of similarity to various genomes within the Alliance. This service supports separate environments for each of the Model Organism Databases (MODs) as well as a unified environment for the Alliance. Results provide detailed alignments and annotations to aid in your research. Explore the various BLAST environments through the links below to find the one that best suits your research needs: Fly BLAST Worm BLAST
FlyBase Gene Report Interactions section, with links to the FlyBase Interactions Browser and the MIST tool highlighted with a pink box.
The Bluesky social media feed on the FlyBase hompage, found directly under the External Resources sidebar on the left side of the page.
Interactive table showing the genes comprising the SWR1 complex.
Map of the vendors at Dros25, with the FlyBase booth prominently highlighted.
Screenshot of the FlyBase Fly Lab List, with the link to add a lab highlighted with a purple box.
Please provide the following to Jessica.Treisman@med.nyu.edu: Name and contact information A 1-page summary of the program, including an explanation of how the program would broaden participation among Drosophila scientists Budget justification of up to $2000
New long read RNA-Seq tracks displayed in JBrowse. These new tracks can be found under Transcript Level Features. Shown here are RNA-Seq long reads encoding novel CDS for the gene Irk2.
A screenshot on the Frequently Used GAL4 and Other Binary System Drivers table showing two newly added lexA drivers.
Links to external resources, including FlyCyc (chitin biosynthesis) and KEGG (Amino sugar and nucleotide sugar metabolism).
A GO Causal Activity Model (GO-CAM) visual representation of the CHITIN SYNTHESIS metabolic pathway.
The Drosophila genes involved in CHITIN BIOSYNTHESIS: Chs2 and kkv.
The FlyBase QuickSearch tool, open to the Pathways tab. The search term CHITIN BIOSYNTHESIS is entered in the search box. The link to the Metabolic Pathway reports browsable list is boxed in purple.
FlyBase Metabolic Pathways report for CHITIN BIOSYNTHESIS.
List of Awardees 2023: For gathering and organizing the information that drives Drosophila research Dr. James Thompson for Drosophila Information Services Dr. Thomas Brody for Interactive Fly FlyBase Curatorial Team: Dr. Giulia Antonazzo, Dr. Helen Attrill, Dr. Lynn Crosby, Dr. Damien Goutte-Gattat, Dr. L. Sian Gramates, Dr. Victoria Jenkins, Dr. Aoife Larkin, Dr. TyAnna Lovato, Dr. Steven Marygold, Dr. Beverley Matthews, Dr. Alex McLachlan, Dr. Gillian Millburn, Dr. Arzu Öztürk-Çolak, Dr. Clare Pilgrim; all past and present curators for their contributions and substantial efforts. 2024: For cataloging, maintaining, and distributing Drosophila stocks for the worldwide research community Bloomington Drosophila Stock Center at Indiana University Senior Staff Members: Dr. Kevin Cook, Dr. Annette Parks, Dr. Cale Whitworth, and Dr. Sam Zheng; all staff members and stockkeepers past and present for their contributions and substantial efforts.
Logo for the Drosophila Community Service Award. Drawing of a wild-type fruitfly, oriented diagonally with the head facing upper left, on a white background. The fly is standing on a light blue ring emblazoned with the text "Outstanding Community Service".
The Navigation panel for a Drosophila melanogaster Gene Report (left) and for a non-Dmel Gene Report (right). Note that the section headings for Genomic Location, Function, Gene Model and Products, Expression Data, Gene ToolKit, Aberrations, Paralogs, Pathways, and Genomic Location and Mapping have been removed for the non-Dmel report.
Picture of a courtyard at the San Diego hotel where the 66th Annual Drosophila Research Conference will be held. Small round tables draped in purple tablecloths are scattered on the courtyard lawn; each table has 4 white folding chairs, with a plastic flamingo as a centerpiece.
The row corresponding to one hit in the Split System Combination hit-list table.
By using the 'Show/Hide Columns' button (boxed in purple), one can select which columns one wishes to view by ticking or unticking boxes in a pop-up menu (also boxed in purple).
The split system results table of a GAL4 etc search. The split system table, on the left, is boxed in purple. The hemidriver table, on the right, is unboxed.
Table of results of a GAL4 etc search. A blue box reading 'Single alleles (includes hemidrivers)' is boxed in purple, as are earch hemidriver allele.
The FlyBase GAL4 etc QuickSearch tab. Only the 'Anatomy/Cell Type' field is filled, with the FlyBase Anatomy Controlled Vocabulary term 'alpha/beta surface Kenyon cell. The tab heading is boxed in purple.
The Combination components section of a FlyBase Split System Combination Report.
The FlyBase GAL4 etc QuickSearch tab. The tab title and the link to the Frequently Used GAL4 Drivers table are both boxed in pink.
The FlyBase Frequently Used GAL4 Drivers table. The dedicated 'Contact FlyBase' link that allows users to contact us about this resource specifically is circled in pink.
The FlyBase Bulk Data Download Page, opened to Expression bulk data files. The file fore High-Throughput Gene Expression is boxed in pink.
The Testis-specificity index is found in the Expression section of Gene Reports. Here, the Testis-specificity index for the gene SdhAL, which has the very high value of 5.16, is shown. SdhAL is a paralog of Sdh (which is ubiquitously expressed, and has a fairly low value).
The browsable list for FlyBase Gene Groups. The gene count for one group is boxed in pink.
The same table, pre-filtered to show only alleles with a GFP tag. This pre-filtered term shows up in a blue oval with white text in the 'Tagged with' filter box (boxed in pink). The second filter term 'FLAG' has also been entered.
The responsive table for the 'Classical and Insertion Alleles' subsection of the VGlut gene report. The 'Tagged with' column (boxed in pink) is being filtered to show only alleles with a GFP tag. A 'plus' symbol at the lower right of the filter box is circled in orange. Clicking this icon allows the user to enter another search term.
The External Data section of the ACF COMPLEX FlyBase Macromolecular Complex group report. The link to the EMBL-EBI Complex Portal entry is boxed in pink.
The Complexes QuickSearch tab, which allows searches of Macromolecular Complex Gene Groups. The group ACF COMPLEX is entered in the search bar. The link to a browsable list of all Macromolecular Complex reports is boxed in pink, while a link to the Vocabularies Gene Ontology Term Report for 'protein-containing complex' terms is boxed in blue.
FlyBase Macromolecular Complex Report for the gene group ACF COMPLEX. This complex has two member proteins (Acf and Iswi), and is a child of the group ISWI COMPLEXES. Associated Gene Ontology terms are also shown on this report.
This table has been further filtered by entering the text string 'red' in the 'Tag use(s) column, narrowing the table to constructs containing red fluorescent protein
Allele table for 'Transgenic constructs containing/affecting the coding region of sqh' on the sqh Gene Report filtered for constructs with a 'Fluorescently-tagged genomic rescue'.
The Transgenic Constructs subsection of the sqh Gene Report, filtered to show all UAS RNAi alleles. The filter boxes for 'Transgenic Product Class' and 'Regulatory region' are boxed in pink, and show they've been respectively filtered by 'RNAi_reagent' and 'UAS'.