James Fraser @fraserlab.com · Feb 18 CJ measured key rate constants that constrained a model to show how lipid binding shifts Orf9b’s equilibrium towards the homodimer, preventing Tom70 interaction. The lipid-free form comes to equilibrium in seconds, whereas the lipid-bound form takes hours-days!
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These results suggest that stabilizing Orf9b’s (lipid-bound) dimeric state could be a future therapeutic target. Disrupting lipid interactions might bias Orf9b towards a form that can’t bind Tom70, restoring immune activation.