Giulia Paci

@giuliapaci.bsky.social

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Physicist having a go at biology, EMBO postdoctoral fellow @UCL in the Mao group, @EMBL alumna

Figure comparing results between control wing discs and Mbs-RNAi discs. Mbs-RNAi cells look straighter in cross section and they acquire fewer neighbours in z. The bottom row shows images and quantification of SOP spacing, with Mbs-RNAi SOPs being closer together
Simulations for uniform, linear and exponential profile of signalling strength along the apico basal axis, with corresponding simulations for 3 different wing disc topologies
Scheme of the modelling framework, showing how a network of cell-cell contacts is extracted from the segmented data
On the left, a plot of cumulative neighbours over the tissue depth showing the number of neighbours roughly doubling. On the right, a color-coded image shows how new neighbours are gained in z for four example cells
Scheme showing how scutoidal cell shapes can give rise to neighbour exchanges along the apico-basal axis
Figure showing the experimental SOP pattern and the ones generated by simulations
Animation showing wing disc cells segmented in 3D