M. Eugenio Vazquez

@glowsticks.bsky.social

1724 Followers 1306 Following

Peptide engineering, supramolecular chemistry, DNA binding, caged molecules, luminescent sensors & chem art. " Tell me, what is it you plan to do / with your one wild and precious life?" —Mary Oliver ORCID: 0000-0001-7500-985X http://www.evazquezlab.gal

Dummy, the debut studio album by English electronic music band Portishead.
An excerpt of a scientific bibliography listing references numbered 4 through 9. Reference number 8, L. Pauling, private communication, is highlighted in yellow.
Change my mind meme with the text “Strauss waltzes at the Vienna New Year’s Concert were basically 19th-century reggaeton”
Black-and-white album cover showing cellist Sonia Wieder-Atherton standing behind her cello with one hand on the fingerboard and the other holding the bow. The title “Bach Cello Suites Nos. 1 & 2” appears in white text at the top right, along with her name. The Alpha Classics logo sits in the bottom right corner.
Screen capture with the initial paragraph of The Atlantic piece: “The story we got about world war ii is all wrong,” a guest told Tucker Carlson on his podcast two weeks ago. “I think that’s right,” replied Carlson. The guest, a Cornell chemistry professor named David Collum, then spelled out what he meant: “One can make the argument we should have sided with Hitler and fought Stalin.” Such sentiments might sound shocking to the uninitiated, but they are not to Carlson’s audience. In fact, the notion that the German dictator was unfairly maligned has become a running theme on Carlson’s show—and beyond.”
Ink drawing of a cell
An older woman speaks seriously on a couch. Subtitle: "Management is not easy. It's watching someone do job worse than you."
Black and white Image of artist Yves Klein wearing a white shirt, dark vest, and bow tie, prominently holding up in the foreground his right hand, which is covered in bright blue paint.
Cartoon showing Prof. Manuel Melle/Franco (left); Prof. Ángel Orte (center-left, holding a fluorescent Erlenmeyer); Soon-to-become-Dr. Carmen González-González (center-right); Prof. Juan Antonio González-Vera (right). Thank you to all!!!
Artistic interpretation showing a concrete alpha helix and neon signs with Es and Ks, representing the luminescent salt bridges.
Time gated emission spectra of 50 µM solutions of DOTA-(E4K4)4 in the presence of 1.0 eq of a) Tb(CF3SO3)3, and b) EuCl3 showing the typical lanthanide emission bands that demonstrate energy transfer from the NAF sequence.
Image of the structure of the (E4K4)4 α-helix and the corresponding helical net diagram showing the stabilizing salt bridges between Glu and Lys residues; UV/Visible absorption spectrum showing the absorption bands and below, the Excitation-Emission Matrix (EEM) showing a clear emission band at 420 nm
Shematic representation of the screening of a SPOT library to identify metallopeptide catalysts. Top of of image shows a microscope slide with the full library then below, the procedure used in the screening as explained in the text, and below an image of the fluorescence, showing a black background with a regular array of bright yellow spots with different intensities, which correlate with the depropargylation of a fluorogenic substrate
Representation of a beta hairpin peptide coordinated to Pd through two His side chains and, on the right, scheme of the depropargylation reaction of the fluorogenic substrate.
A protein alpha helix glowing in green over a black background
Book cover of “ship of Theseus” showing a sail ship on a cloth hardcover
Black and white image of an overcast winter day and an old mossy stone bridge in the background. The photo was taken with a long exposure and shows the river as a blured surface.
Scheme of the screening of catalytic metallopeptides. a) Left: The structure of a trpzip hairpin indicating as stubs the positions mutated in the screening (1 to 12 from N- to C- terminus), right: schematic representation of the trpzip hairpin indicating the positions of the screening; b) Fluorescent readout and results of the screening of the probe; c) Screening of the CelluSPOT library. The catalytic metallopeptides are identified by their position in the array, and their relative activity quantified by the emission of each spot at increasing incubation times.
Selecting a catalytic metallopeptide from a spot library. A microscope slide with the library is shown on the left, together with the structure of a metallopeptide (Palladium peptide catalyst) on the right.
Using (E4K4)4 as antenna to sensitize Tb(III) and Eu(III). The image shows the structure of the (E4K4)4 peptide with a DOTA chelator, and below the time gated emission spectra of 50 µM solutions the peptide in the presence of 1.0 eq of a) Tb(CF3SO3)3, and b) EuCl3 showing the characteristic peaks of both lanthanides.
Intricate instrument cluster of the Bugatti Tourbillon, designed and built with the expertise of Swiss watchmakers.
Ron Swanson from Parks and Recreation saying "This is my hell"
Figure showing a short double-stranded DNA (Dickerson's dodecamer) with a benzamidine inserted in the minor groove in its central region with the AATT sequence. The backbone is colored according to the changes in the DNA chemical shifts shown on the left, aligned with the DNA.
Schematic structure of a 310-helix showing bent hydrogen bonds. On the right, an alpha helix has nearly ideal H bonds, and so they are represented as straight lines.
Sample page from Dickerson and Geis' "The structure and action of proteins" showing the different types of helical secondary structures in proteins. At the top of the image, from left to right, 310 helix, alpha helix, and pi helix; at the bottom of the image, the hydrogen patterns of each type of helix.
Cover of the 1969 book The Structure and Action of Proteins" with a simplified represenetation of hemoglobin drawn by I. Geis
The left and right sides show two proteins as ribbons on an abstract green background. An azobenzene, shown as sticks and a transparent surface, is bound to each protein.
Screen capture with “Carolyn Bertozzi followed you back” message from BlueSky
13th Edition Merck index and photographer Chema Madoz book as decoration on a coffee table.
Image of a fox and a hedgehog and quote below: “Scientist come in two varieties, hedgehogs and foxes [...] Foxes know many tricks, hedgehogs only one. Foxes are broad, hedgehogs are deep. Foxes are interested in everything and move from one problem to another. Hedgehogs are only interested in a few problems that they consider fundamental, and stick with the same problems for years.” By Freeman J. Dyson from his book “A many-colored glass”
Image of the the Microvenus icon that represents life and the female earth and resembles the letter Y with an upwardly extended vertical line. This icon can be encoded and stored as a DNA sequence
Promo image of the Apple TV show “Slow horses”
Plot showing both excitation and emission spectra of a short peptide composed of Lys and Glu residues. Excitation maximum at c.a. 340 nm and emission maxium at about 440 nm.
gif image showing general Zod, from the 2013 film "Man of Steel", calling HERESY
Plot showing both excitation and emission spectra of a short peptide composed of Lys and Glu residues. Excitation maximum at c.a. 340 nm and emission maxium at about 440 nm.
"An image in which Maxwell's spot can be observed" An array of black stars over a bright blue background. Some stars appear to be greenish and brighter than the other ones. Moreover, the blue background of the area appears to be darker (denser) than the surround or appears to be purple.
Image of an eye showing color-dependent focus planes
screen capture with the following message informing of a grant successfully submitted: Your proposal was submitted on: 20 August 2024 15:16:56 (Brussels Local Time) Your proposal is part of call ERC-2024-ADG. The call deadline is 29 August 2024 17:00:00 (Brussels Local Time).
screenshot showing a $ 4000 open access charge, and a $ 4000 discout thanks to University agreements with the journal.
The ring flip of a carbohydrate is employed for the tongs-like movable component of a metal ion sensor. A pair of separated pyrene groups attached to the carbohydrate component are placed side by side when it recognizes metal ions, affording excimer fluorescence. This novel molecular sensor is selective for Zn2+ and Cd2+.
The image displays two sets of characters against a white background. The top row shows "B8 1IiI" in a clear, bold font. Directly below it, the same characters are shown, but in a blurred and less distinct form, making them appear out of focus to demonstrate the clarity of the font or the visual difference between the sharp and blurred versions of the same text
Oscar Wilde’s Ballad of Reading Gaol book open in the title page