Greg Findlay

@gregfindlay.bsky.social

466 Followers 269 Following

Group Leader The Genome Function Laboratory The Francis Crick Institute, London

Correlations between PETRA expression scores and outputs of sequence-to-expression models.
Correlation of expression scores between Jurkats and primary T cells.
Map of combinatorial MYBL2 and EGR1 motif insertions to IL2RA with expression scores for all possible combinations.
Variants from the initial screen were re-tested in a smaller library for validation, confirming strong effects.
PETRA enables expression effects to be read out via amplicon sequencing of edited loci.
PETRA workflow
A Sankey plot of functional evidence derived for BRCA1 variants using SGE across cell lines
Mapping function score for BRCA1 variants to evidence codes to support clinical classification.
ROC-AUC cruves for prediction of pathogenic BRCA1 variants using SGE data
Comparison of SGE function scores in HMECs with and without PARP inhibitor treatment.
function scores for BRCA1 variants in exons 11 and 12, measured in HAP1 cells and HMEC cells
schematic of a new SGE assay in human mammary epithelial cells
effects of variants measured across the BRCA1 gene
A sequence-function map of variants in BRCA1 produced in 2018 using saturation genome editing.