Sarah Hainer

@hainerlab.bsky.social

913 Followers 303 Following

Assistant Prof @PittBioSci studying transcription dynamics and chromatin biology | passionate about equity in STEM | she/her

Enhancer-promoter loops impacted by BRG1 or INO80 loss are enriched for OCT4, SOX2, NANOG and SUZ12, and are described as bivalent locations.
Promoter capture microC (PCMC) enriches for TSS-based loops and shows decreased loops in Brg1 KD and increased loops in Ino80 KD
Our Hi-C data detects limited TSS-based loops, but is enriched for CTCF-based (architectural) loops
Hi-C data analyzed for TAD structures
subcompartment analysis of Hi-C data showing impact of remodeler depletion on subcompartments
heatmaps from Hi-C data showing compartment structures
Kya holding her certificate of award for poster presentation