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We invest in scientists at all career stages who make discoveries that advance human health for decades to come.

A fibroblast (green) with the outermost layer of skin (red) and collagen fibers (blue). Courtesy of Shuangshuang Du.
Microscopy image of a diatom viewed head-on against a black background, revealing an intricate honeycomb-like silica shell (frustule) in extraordinary detail. Thousands of tiny hexagonal pores cover the circular surface, transitioning from warm amber and gold at the top to vivid teal and blue-green toward the center and bottom. A delicate starburst or rosette pattern is visible at the lower center, converging on a single dark central point. The overall effect is geometric and jewel-like, resembling stained glass or a mosaic.
Fluorescence micrograph of a cross-section through a developing mouse femur. At the center, densely packed yellow-gold structures — blood vessels — are surrounded by a luminous white interior. Blue-gray osteoclasts ring the inner cavity, and vivid red tissue forms the outer boundary of the developing bone. The surrounding tissue fades to soft purple and pink at the edges. The overall composition is circular and jewel-like, resembling an abstract painting.
Steven Henikoff in his lab
Newly Elected EMBO Associate Member Rachel Green HHMI Investigator Johns Hopkins University
A neuron with clumps of tau (bright dots). Courtesy Kathleen McCann, Parker Lab.
Connie Cepko in her lab
Three stentors
Arabidopsis thaliana, grown in the Dinneny lab. Courtesy Yue Rui.
Tobias Walther in his lab
Corina Amor Vegas in her lab
Demisds imaged with confocal microscopy — cell walls in blue, chloroplasts in red
2 HHMI Freeman Hrabowski Scholars receive the 2026 McKnight Scholar Award Timothy Machado, University of Pennsylvania Kara Marshall, Baylor College of Medicine
A rare moment caught in stunning detail: a single cell splitting into three. Seen here in cancerous pig cells, it marks the first time such an event has been captured on video — made possible by MOSAIC's 5D imaging. Courtesy of Advanced Bioimaging Center/UC Berkeley.
Mary Gehring in her lab
Vivid layers in green, brown, and purple are retinal pigment epithelial cells, or RPEs.
Kafui Dzirasa in his lab
Summer undergraduate researchers in the lab of Dr. Xin Chen, HHMI Investigator.
2 HHMI Investigators elected as Fellows of the Royal Society Michael Elowitz (CalTech) Yang Dan (Emeriti)
HHMI Investigator Massimo Scanziani (left) and graduate student Sophie Grutzner (right) discuss her research data.
Mouse neurons courtesy of Christophe Leterrier, NeuroCyto Lab, INP, Marseille, France, via NIH BRAIN Initiative.
Josh Dudman (left) and Luke Coddington (right) at HHMI's Janelia Research Campus
96-channel electronic pipette that helped HHMI Investigator Paul Bieniasz & colleagues at Rockefeller University run 7,000+ parallel experiments that uncovered more than 100 bNAb escape mutations across 15 viral strains.
Text: Applications Open Presidential Fellows Program Background of HHMI's HQ
This image shows the model at work on a microscope image, with each cell marked in its own distinct color.
Rainbow fluorescent dyes from the Lavis Lab
HHMI Investigator Michel Nussenzweig in the lab
The extracellular matrix (ECM). Red/orange waves = ECM molecules; blue ovals = nuclei.
10 HHMI Investigators elected to the National Academy of Sciences: - Jesse Bloom, Fred Hutchinson Cancer Center - Clifford P. Brangwynne, Princeton University - Ralph J. DeBerardinis, UT Southwestern Medical Center - Chuan He, The University of Chicago - Stephen Liberles, Harvard Medical School - Vanessa Ruta, The Rockefeller University - Pardis C. Sabeti, Harvard University - Russell E. Vance, University of California, Berkeley - Johannes Walter, Harvard Medical School - Yi Zhang, Boston Children’s Hospital
Freeman Hrabowski Scholar Siniša Hrvatin examining a specimen in the lab
5 HHMI Investigators elected to the American Academy of Arts & Sciences. Pictures of: Olga Boudker, William Jacobs (Emeriti), Michael Shadlen, Kim Orth, Leslie Vosshall
When inflammation strikes, skin stem cells in mice (green) spring into action & produce more of a protein called H2A.Z (red). This protein helps lock in the long-term "memory" of inflammation. Courtesy of the Fuchs Lab.
Confocal microscopy image of Aspergillus fungus against a black background. Dense, intertwining filaments (hyphae) in blue, gold, and orange stretch across the lower portion of the image, while characteristic spore-bearing structures (conidiophores) rise upward, their globe-like spore heads rendered in vivid blue with orange and red accents. Two bright orange-gold filaments run horizontally across the middle of the frame. The overall effect is strikingly ornate, resembling an abstract or botanical illustration.
Janelia Group Leader Jiefu Li (right) and his team are uncovering how the blood-brain barrier functions.
HHMI Investigator Stuart Orkin 2026 Breakthrough Prize in Life Sciences
HHMI Investigators Michael Rosen (L) and Eric Gouaux (R) and collaborators Rosana Collepardo-Guevar (L) and Magdalena Schneider (R) examine a cryo-electron microscope at our Janelia Research Campus, a key tool in developing AI-powered imaging inside cells.
Current Gilliam Fellow Denethi Wijegunawardana pictured with Investigator & former HHMI President Tom Cech.
Educators gather around a table during an HHMI BioInteractive teacher training workshop, examining a hands-on science activity with materials in a tray.
Researchers combined liver cells with tiny, uniform gel spheres to create small, stable “mini livers” that can function like real liver tissue. Courtesy of the Bhatia Lab.