HMS Image Analysis Collaboratory

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News from the Image Analysis Collaboratory at Harvard Medical School. Teaching, research and promoting best practices in Bioimage Analysis. Get in touch: https://iac.hms.harvard.edu/.

Abstract: Three-dimensional subcellular imaging is often hampered by diffraction limits in thick, heterogeneous tissues and invalid assumptions about data distribution and imaging systems. We introduce SSAI-3D, a weakly physics-informed, domain-shift-resistant framework that robustly achieves isotropic 3D imaging. Demonstrations in various label-free samples, plus validation on publicly available 3D datasets with unknown blurring and noise, confirm its potential for more accurate subcellular analysis.