InterPro

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InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. ebi.ac.uk/interpro/

InterPro page with a list of the quinoa sequences in UniProtKB that belong to the HSP70 family.
InterPro Feature Spotlight: Taxonomy Sunburst View
InterProScan 6 (beta) Nextflow - Containerised - Reproducible outputs Start with FASTA file InterProScan workflow: Annotate proteins (and nucleotides) with families, domains & sites Select analyses (e.g. Pfam, PANTHER, CDD, NCBIFAM...) Optional: GO and pathway annotations Output formats: JSON, TSV, XML, GFF3
Poster A-098: Pfam database in 2025 – towards expanding protein families coverage Nicole Morveli Flores Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
JOBIM 2025 logo 8 to 11th July 2025 Bordeaux
Schematic diagram showing taste signal transmission between the tongue (with taste buds that contain taste cells harbouring GPCRs) and brain. Taste GPCRs are activated by specific food compounds, recruit specific G proteins that further induce intracellular calcium release. Adapted from [https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28:_Biosignaling_-_Capstone_Volume_I/28.18:_Signal_Transduction_-_Taste_(Gustation)].
InterPro 106.0 19th June 2025
CATH-Gene3D annotation visualised on BFVD structure prediction of UniProt A0A075FDU7
TED domains alongside InterPro annotations for UniProt P05067
InterPro 105.0: AI for protein classification InterPro 105.0 is now live. This AI-driven update makes it easier than ever to explore the protein universe
InterPro 105.0 24th April 2025
LLM generated summaries for protein classification at InterPro
InterProScan Version: 5.73-104.0 6th February 2025
InterPro 104.0 6th February 2025
Parkinson's disease molecular mechanisms. Source: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61393-3/fulltext#fig3
InterPro website Help page
Example of Profile HMM page for Pfam PF22971. It contains HMM data and Profile HMM logo
Video showing how to use the curation status filter on InterPro
InterProScan 5.72-103.0 release notes: Synchronized with InterPro version 103.0. The addition of 1029 InterPro entries. An update to Pfam (37.1). Integration of 1019 new methods from the CDD (7), NCBIfam (2), PANTHER (1), PIRSF (1), Pfam (1008) databases.
AI-filter in InterPro
InterPro release 103.0: 28th November 2024
InterPro: a database classifying proteins Content: 13 resources in one places Content: over 46,000 entries describing protein families and protein domains Part of Elixir and Global biodata coalition Training available on the EMBL-EBI training platform