Jacob Jameson 📊 @jacobjameson.com · Nov 30 Across different cohorts, low ploidy 📉 and high heterogeneity 📈 robustly identify patients with intrinsic resistance to aPD-1 therapy
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The decision tree model using heterogeneity & ploidy achieved: ✅ High specificity (97%) ✅ Strong PPV (90%) This helps identify patients unlikely to benefit from single-agent aPD-1 ICB, who might need combo therapies.