JAMA

@jama.com

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JAMA is an international peer-reviewed general medical journal and a member of the JAMA Network family of journals. 🌐 JAMA.com

Podcast cover for "Healthy Dialogue." Illustration of a smiling man, Derek C. Angus, MD, MPH, with glasses and swept-back hair, in red tones against a red background. A red circular logo with white letters "JN" is in the lower right.
JAMA Clinical Guidelines Synopsis: Ulcerative Colitis Management in Adults, published July 22, 2026. Details major recommendations including C. difficile testing, fecal calprotectin, & treatments like 5-ASA or corticosteroids.
JAMA Research Letter: Trends in patient portal messages, office visits, & telephone encounters, Q1 2020-Q4 2025. Four line graphs show rising patient portal message rates & intensity. Telehealth spiked dramatically early on, then stabilized. Office visits & phone calls remain stable.
JAMA study: Finerenone for chronic kidney disease (glomerular). Conclusion: Finerenone slowed kidney function loss. Population: 903 adults (541M/362F, mean 51) from 24 countries. Finerenone group (446) eGFR slope -3.50, Placebo (457) -4.23 mL/min/1.73m²/year. Hazard ratio 0.74.
JAMA Editorial titled: "New Dyslipidemia Guidelines Lower the Lipid Treatment Goals and Raise the Bar for Clinical Practice." Authored by Philip Greenland, MD, and Karen E. Lasser, MD, MPH. Published online July 20, 2026.
JAMA Research Letter: "Prevalence of LDL-C Above 2026 Dyslipidemia Guideline Goals Among US Adults." Table 1 presents weighted prevalence data for US adults not meeting LDL-C goals, categorized by age, sex, and race/ethnicity across primary and secondary prevention risk groups.
JAMA Research Letter: Cardiovascular Risk Reclassification with the 2026 Dyslipidemia Guideline. Figure 1 presents a bar graph comparing 10-year ASCVD risk by PCEs vs PREVENT-ASCVD, and a matrix on risk recategorization: 14.2% lower, 78.5% unchanged, 7.3% higher.
JAMA Clinical Guidelines Synopsis titled 'Dyslipidemia Evaluation and Management,' published July 20, 2026. Details 2026 ACC/AHA guidelines for dyslipidemia, including ASCVD risk assessment, lipid-lowering therapy, Lp(a) measurement, and treatment recommendations for children & adults.
JAMA flowchart: 'Implications of the 2026 Dyslipidemia Guideline for Primary Prevention Statin Therapy'. It shows statin recommendations (strong, moderate, none) for nonpregnant adults 30-79, categorized by risk factors like LDL-C, diabetes, CKD, HIV, and 10-year ASCVD risk, with population estimates.
JAMA Journal of the American Medical Association cover, July 14, 2026. The cover features sections like Research, Opinion, and Clinical Review & Education. A large banner at the bottom reads: "This Week's Issue of JAMA July 14, 2026."
Figure 2 from JAMA: A line graph comparing mean change in iADRS score for Ceperognastat (0.75 mg, 3 mg) versus Placebo over 100 weeks in early Alzheimer's. The 3mg Ceperognastat group shows a greater decline (worsening) in iADRS score than placebo. A table of participant numbers is below.
JAMA article title: Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease. Bubble graph showing the association between Gaussian mixture model peaks and cognitive impairment. Higher peak (orange) shows an upward trend (ß=20.2, P<.001). Lower peak (blue) shows a slight downward trend (ß=-8.8, P<.001).
JAMA journal page. Editorial titled "Threshold in Focus—Defining Amyloid Positivity on the Centiloid Scale" by Nasrallah & Brown, published July 13, 2026. Discusses amyloid PET in Alzheimer's research & clinical care, and defining positivity on the Centiloid scale.
JAMA article: 'Ceperognastat in Early Symptomatic Alzheimer Disease'. Figure 2 line graph displays mean iADRS score change vs. placebo over 100 weeks. Ceperognastat 3mg shows a greater decrease than 0.75mg and placebo. Disease progression ratios at week 100 are also given. Participant numbers listed below.
Bubble graph from JAMA, titled "Amyloid PET Quantitation & Centiloid Thresholds in Alzheimer Disease". X-axis: "Cognitively impaired, %"; Y-axis: "Gaussian peaks in Centiloids, %". Orange bubbles (Higher peak: β=20.2, P<.001) show an upward trend. Blue bubbles (Lower peak: β=-8.8, P<.001) show a slight downward trend.
JAMA Neurology: Trends in Dementia Prevalence Across Latin America and the Caribbean. Bar graph shows age- and sex-standardized dementia prevalence in 5 countries for 2003-2006 (blue) and 2016-2020 (orange). Most countries, like Peru, Mexico, and Puerto Rico, show an increase in prevalence over time.
JAMA Figure 2: Clinicopathologic Evaluation of Amyloid Clearance in Alzheimer Disease. Panels A-C display beta-amyloid plaques & clearance in brain tissue; D-F show phosphorylated tau pathology, reactive microglia & astrocytes at various magnifications. Published July 12, 2026.
JAMA editorial: 'Ruling Out PE in Cancer—Can YEARS Reduce CT Imaging?' by Henry B. Han, MD; Joshua A. Beckman, MD. Published online July 12, 2026. Article discusses the YEARS algorithm for reducing CT imaging for pulmonary embolism in cancer patients.
JAMA Research Letter: "Trends in National Institutes of Health Investigators by Sex, Race, Ethnicity, and Disability Status." Two line graphs, 2016-2025. Graph A: project grants increase from ~40k to ~49k. Graph B: fellowships peak at ~4.2k in 2020, end at ~3.6k. Published June 8, 2026.
JAMA table: "Management of Spontaneous Abortion Among Commercially Insured Individuals in the US After Dobbs v Jackson." Compares Pre- & Post-Dobbs data for states with trigger bans (n=14) & comparison states (n=17). Spontaneous abortions for less than 77 days' gestation show a decrease post-Dobbs, with significant shifts in annual reporting from 2022.
JAMA article: 'Incentivizing Kidney Transplants While Safeguarding Equity'. Authored by Courtney M. Rentas, Lisa M. McElroy, Silas P. Norman, et al. This Viewpoint was published online by JAMA on June 3, 2026. DOI: 10.1001/jama.2026.8838.
JAMA editorial: 'Ruling Out PE in Cancer—Can YEARS Reduce CT Imaging?' by Henry B. Han, MD; Joshua A. Beckman, MD. Published online July 12, 2026. Article discusses the YEARS algorithm for reducing CT imaging for pulmonary embolism in cancer patients.
JAMA study on YEARS algorithm for PE in cancer. Conclusion: YEARS is as safe as CTPA for excluding acute PE, avoiding CTPA scans. Population: 422F, 276M, median 65. 698 randomized, 555 analyzed. Intervention: YEARS (352) vs CTPA (346). Findings: PE-related death YEARS 1.8%, CTPA 5.5%. YEARS not inferior.
Infographic on Chikungunya, a viral infection spread by mosquitoes. Features a detailed mosquito image and an insect repellent bottle (30% DEET). Text describes symptoms like fever & joint pain, and outlines prevention methods: using repellents, wearing protective clothing, screens, AC, and eliminating standing water.
JAMA Review: Survivors of Cyanotic Congenital Heart Disease. Figure 2 illustrates 4 anatomic isthmuses for monomorphic ventricular tachycardia in Tetralogy of Fallot. Three heart diagrams show Isthmus 1 (RVOT patch), Isthmus 2 (ventriculotomy/pulmonary valve), and Isthmus 3 & 4 (VSD patch/annuli). Text describes each.
JAMA Viewpoint article titled "Beyond Binary—The Case for Amyloid Centiloid Quantification" by N. A. Chin, C. M. Erickson, J. D. Grill, et al. Published Online: June 17, 2026. DOI: 10.1001/jama.2026.10733.
JAMA flowchart: "Cost-Effectiveness of Fecal Immunochemical Testing Alone vs Co-Testing With Helicobacter pylori Stool Antigen." It details clinical events, comparing individuals with/without H. pylori, early colon cancer, and colon adenoma, showing test results & treatment paths.
JAMA Viewpoint article: 'Alzheimer Disease Biomarkers and Assisted Dying: When Diagnosis Becomes a Deadline.' Authors include Stanley Lyndon, Lauren M. Behlke, Juan Carlos Urizar, et al. Published online July 9, 2026. The page shows navigation options.
Human torso shows a labeled liver, surrounded by Hepatitis B virus particles, with a syringe icon. Text explains Hepatitis B as a viral liver infection transmitted via blood/fluids, distinguishing acute/chronic forms, and emphasizing vaccination as effective prevention for all ages.
JAMA Research Letter: Deaths Caused by Law Enforcement in the US (Published July 8, 2026). Figure shows death rates by age group (adults, children) & by sex, race/ethnicity from 2003-2024. Adults have higher rates than children. Male Black individuals consistently show highest rates.
JAMA editorial 'New Lungs for Lung Cancer— Perils and Promises' by Ece Cali Daylan, MD, PhD¹ and Ramaswamy Govindan, MD1,2. Published online July 8, 2026. DOI: 10.1001/jama.2026.11478.
JAMA: Lung Transplant for Refractory Lung-Limited Stage IV Non-Small Cell Lung Cancer. Kaplan-Meier plot shows overall survival (%) over 500 days post-transplant for groups including Stage IV lung cancer, no cancer, bilateral, & single lung recipients, with survival rates generally above 80%. 'No. at risk' table below.
Smiling woman with wavy brown hair and tortoiseshell glasses, wearing a dark blazer over a blue top with pink stripes. She has a gold necklace with metallic beads. The background is a plain gray gradient.
JAMA flowchart: Cost-effectiveness of fecal immunochemical testing vs co-testing with H. pylori stool antigen. Published June 1, 2026. Diagrams clinical pathways for individuals based on H. pylori infection, early colon cancer, or colon adenoma status, showing test results and outcomes.
JAMA: 'Surgical & Endoscopic Therapies for GERD.' Table: 'Antireflux Endoscopic Therapies for GERD,' detailing clinical criteria for patient conditions & corresponding treatment recommendations. Published July 1, 2026.
JAMA Viewpoint article titled "Beyond Binary—The Case for Amyloid Centiloid Quantification" by N. A. Chin, C. M. Erickson, J. D. Grill, et al. Published Online: June 17, 2026. DOI: 10.1001/jama.2026.10733.
A stack of medical journals showing 'JAMA' in black text on white covers with red spines. Below it, text reads: 'July 2 ¡ 15 min Social Media Use by Adults for Health Information, Socia... JAMA Editors' Summary' and a 'Play' button.
Stylized head with medical symbols (stethoscope, syringe, Rx, Caduceus, ambulance, pills, heartbeat) flowing from its open brain, connected by arrows. Text: 'Alzheimer Disease Blood Test May Have Higher Rate o... JAMA Medical News'. 'Play' button.
JAMA Research Letter, June 30, 2026: 'Use of Social Media for Health Information Among US Adults'. Dot-and-whisker plots show associations between demographic characteristics (age, sex, income) and health outcomes: social media use, info sharing, online communities, health decisions, and perceived misinformation.
JAMA Insights table: Surgical & Endoscopic Therapies for GERD. It lists clinical criteria & recommendations for antireflux endoscopic therapies. For small hiatal hernia, transoral incisionless fundoplication is recommended. For large hiatal hernia, concomitant transoral incisionless fundoplication.
JAMA, July 1, 2026. Research letter: Effect of Recruitment Video Presenter Sex on Trial Enrollment. Figure 2: Dot-and-whisker plot of enrollment effects by presenter sex. Most absolute differences are near zero with wide CIs. Age interaction P-value: .02a.
JAMA: "Neonatal Survival After Serial Amnioinfusions for Anhydramnios Due to Fetal Kidney Failure (RAFT Clinical Trial)", published July 1, 2026. Fig 2 Kaplan-Meier curve shows neonatal survival. Fetal kidney failure (orange) has higher survival than bilateral renal agenesis (blue) over 350 weeks.
JAMA Clinical Guidelines Synopsis: Antiviral Therapies for Adults With Mild to Moderate COVID-19 Infection, published June 30, 2026. Details the 2025 guideline update by IDSA, including recommendations for managing mild to moderate COVID-19.
JAMA article, 'Viewpoint | AI in Medicine,' titled 'Specialized or General-Purpose—The Wrong Question for Mental Health AI Safety' by Benjamin W. Nelson, Mark Kalinich, John Torous. Published online June 29, 2026.
JAMA Insights article on Familial Hypercholesterolemia (FH) by Stein & Tattersall, published June 29, 2026. It describes FH as a genetic disorder causing high LDL-C, increasing ASCVD risk. Discusses diagnosis criteria, prevalence, and genetic screening. Includes multimedia links.