JAMA Internal Medicine

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JAMA Internal Medicine is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications. 🌐 JAMAInternalMed.com

JAMA Internal Medicine article: 'Viewpoint: Hantavirus on a Nature Cruise and the Risk of a Pandemic'. Authored by Daniel J. Morgan et al. Published Online: July 9, 2026. Features options for author affiliations & article information.
JAMA Internal Medicine RCT: Respiratory Outbreak Mitigation with Point-of-Care Testing in Long-Term Care. A study in 20 Canadian nursing homes (3963 beds) comparing point-of-care vs standard testing found no significant difference in outbreak number/size between groups (rate ratio 1.12, P=.55).
JAMA Internal Medicine, Original Investigation on Women's Health: 'Prenatal Acetaminophen (Paracetamol) Use & Risk of Autism/ADHD Among Sibling-Matched Cohorts' by Luo et al. Published online June 29, 2026. DOI: 10.1001/jamainternmed.2026.2215
RCT summary: Mindfulness-Based Group Medical Visits for Chronic Low Back Pain. 451 adults (133M, 318F, avg 52.1y) at 3 US sites. 224 received MBSR, 227 usual care. MBSR showed significantly greater pain improvement (PEG score change -1.21 vs -0.59; P<.002), with more participants reporting improvement.
Table 2: Adjusted Primary & Secondary Outcomes. Compares Usual care vs. E-screening results. For ITT, E-screening shows higher % completed (74.4 vs 43.9) & positive results (10.6 vs 2.7). Similar trend for PP: completed (88.3 vs 46.4) & positive (13.2 vs 2.9).
A JAMA Internal Medicine article: 'Apolipoprotein L1 Gene Genotype and Kidney Outcomes After Living Kidney Donation.' Authors include Chi-yuan Hsu, Ying Gao, Barry I. Freedman, et al. Published online June 22, 2026. DOI: 10.1001/jamainternmed.2026.0996.
A JAMA Internal Medicine article: 'Apolipoprotein L1 Gene Genotype and Kidney Outcomes After Living Kidney Donation.' Authors include Chi-yuan Hsu, Ying Gao, Barry I. Freedman, et al. Published online June 22, 2026. DOI: 10.1001/jamainternmed.2026.0996.
JAMA Internal Medicine Research Letter: 'Financial Incentives to Address Representativeness in Randomized Clinical Trials: A Secondary Analysis of RETAIN.' By J.S. Benson, B.P. Patel, B. Bayes, et al. Health Equity topic. Published June 22, 2026.
A JAMA Internal Medicine article: 'Apolipoprotein L1 Gene Genotype and Kidney Outcomes After Living Kidney Donation.' Authors include Chi-yuan Hsu, Ying Gao, Barry I. Freedman, et al. Published online June 22, 2026. DOI: 10.1001/jamainternmed.2026.0996.
A JAMA Internal Medicine article: 'Apolipoprotein L1 Gene Genotype and Kidney Outcomes After Living Kidney Donation.' Authors include Chi-yuan Hsu, Ying Gao, Barry I. Freedman, et al. Published online June 22, 2026. DOI: 10.1001/jamainternmed.2026.0996.
Page from JAMA Internal Medicine showing an Original Investigation: "Estimated Effectiveness of 2024-2025 COVID-19 Vaccines in Adults." Authors include Ryan E. Wiegand, Amanda B. Payne, Josephine Mak, et al. Published online June 15, 2026.
Figure 2 displays two line graphs (A, B) tracking General Cognitive Performance (GCP) over 60 months, based on delirium and rehospitalization. Graph A shows absolute scores; B is offset. Both indicate declining GCP, with lower scores linked to delirium and rehospitalizations. Participant numbers are tabled below.
Line graph of cumulative COVID-19-associated MACEs risk for 2024-2025. Unvaccinated people show a higher, increasing risk (over 5 per 10,000 by 8 months) compared to vaccinated individuals, whose risk remains lower (below 3.5 per 10,000).
JAMA Internal Medicine RCT summary: Spinal Manipulation (SMT) and Clinician-Supported Self-Management (SSM) for chronic low back pain. 1000 patients randomized across 4 groups. SSM showed significantly lower LBP impact scores vs Medical Care (MC). SMT and MC did not differ.
Flowchart "Approach to Joint Pain in Older Adults" starts with Joint Pain, branching into Chronic, Acute, and Noninflammatory pain types. Each branch details symptoms, diagnostic criteria, and leads to conditions like Rheumatoid arthritis, Septic arthritis, or Osteoarthritis. Body diagrams highlight affected joints.
Flowchart "Approach to Joint Pain in Older Adults" starts with Joint Pain, branching into Chronic, Acute, and Noninflammatory pain types. Each branch details symptoms, diagnostic criteria, and leads to conditions like Rheumatoid arthritis, Septic arthritis, or Osteoarthritis. Body diagrams highlight affected joints.
Line graph: HbA1c changes over 12 months in 257 low-income, uninsured Hispanic adults with Type 2 Diabetes. Intervention group dropped from 9.2% to 8.2%, while control stayed stable at ~8.8%.
Two graphs display General Cognitive Performance (GCP) trajectory for N=560 over 60 months post-surgery. X-axis: Time since surgery, Y-axis: GCP score. Graph A is 'Offset by mean difference in GCP score'; Graph B is 'Not offset'. Both compare GCP trajectories for groups with/without delirium and rehospitalizations, showing declines. Tables below list participant numbers for each group.
Conceptual diagram of study findings on barriers to medication management. Concentric circles show individual, interpersonal, and system/policy barriers faced by older adults, along with potential solutions. "Figure. Conceptual Diagram of Study Findings"
JAMA article: 'Measured & Estimated Glomerular Filtration Rates & Risk of Adverse Health Outcomes.' Figure 1 displays density & box plots for GFR distribution using mGFR, eGFRcr, eGFRcys, & eGFRcr-cys. GFR range: 15-120 mL/min/1.73 m². Published June 4, 2026.
JAMA study on rivaroxaban for advanced CKD. Question: Does low-dose rivaroxaban reduce cardiovascular events vs placebo? Conclusion: No reduction in events, but increased major bleeding. Findings: Rivaroxaban 22.6% (164/727) events vs Placebo 20.7% (151/731). Bleeding: 8.8% vs 6.0%.
JAMA Internal Medicine RCT summary: Spinal Manipulation (SMT) and Clinician-Supported Self-Management (SSM) for chronic low back pain. 1000 patients randomized across 4 groups. SSM showed significantly lower LBP impact scores vs Medical Care (MC). SMT and MC did not differ.
Figure 1: Dot graphs of blood pressure. A) Probability of remeasurement: After 140 mmHg initial systolic BP, 'Hypertension control financial incentive' (orange squares) shows higher probability than 'No hypertension control financial incentive' (blue circles). B) Lowest minus highest BP difference: After 140 mmHg, incentives show a greater negative difference.
Conceptual diagram of study findings on barriers to medication management. Concentric circles show individual, interpersonal, and system/policy barriers faced by older adults, along with potential solutions. "Figure. Conceptual Diagram of Study Findings"
Article from JAMA Internal Medicine titled, "Homicide Risk During 10-Day Waiting Period Among First-Time Handgun Purchasers in California." Authors: Sonja A. Swanson, ScD@1; Yifan Zhang, PhD@2; Ian Troidl, MPH@1; et al. Published online May 26, 2026.
Two ECGs: The first, labeled "ECG at admission", shows relatively flat lines with minor variations. The second, "ECG after treatment", displays more pronounced and frequent spikes and dips, showing change in heart activity after treatment.
Conceptual diagram of study findings on barriers to medication management. Concentric circles show individual, interpersonal, and system/policy barriers faced by older adults, along with potential solutions. "Figure. Conceptual Diagram of Study Findings"
Box and whisker plots showing the effects of testosterone replacement therapy and placebo on lean mass, muscle strength, physical function, and aerobic performance. Graphs include whole body lean mass, appendicular lean mass and VO2 max.
The image contains two line graphs comparing 'Privately insured comparators' and 'Eligible Medicare beneficiaries' from 2021 to 2024. Graph A shows 'Cost-related medication nonadherence,' while Graph B shows 'Health care-related financial strain'.
Flowchart: Anxiety Treatment Options. Clinical evaluation includes assessing history of present illness, physical/lab exams. Differential diagnosis covers subthreshold anxiety, other psychiatric disorders. Treatment: behavioral or pharmacotherapy.
Bar graph of adjusted shares of turnover by burnout status shows turnover % for overall, leave practice, and move practice. Burned out vs. not burned out are compared for each category, with burned out consistently higher.
Bar graph compares 911 dispatchers vs CPR instructor agents on CPR instruction, showing checklist criteria satisfied. Agent performance is higher for both minimally viable (p=.02) and maximally effective (p<.001) criteria.
Visual representation of PCOS clinical presentations across life stages. Adolescence: weight gain, irregular cycles. Early adulthood: overweight/obesity, subfertility. Late adulthood: metabolic disturbances, endometrial cancer risk. Struggles with weight.
Recommendations for clinicians to provide linguistically accessible care, including preencounter(ask preferred language), during the encounter(opt for in-person interpretation), and postencounter(debrief with the interpreter).
Line graph: Broker Enrollment Rates in Medicare Advantage Over Time. X axis: Year(2014-2022). Y axis: Enrolled by broker, %. Two lines showing new enrollees & enrollees renewed. Enrollees renewed increase to ~70% while new enrollees increase to ~45%.
Bar graph showing the impact of jail-based Hepatitis C Virus(HCV) interventions on HCV infection. X axis shows outcome, which includes person-years of infection, incidence, and HCV-related deaths. Y axis shows relative reduction, %.
JAMA Internal Medicine presents a research letter on Health Equity, titled 'Self-Reported HIV Testing and Diagnosis Prevalence Among US Hispanic or Latino Adults' by Jonathan Ross et al. Published online May 18, 2026.
Box and whisker plots showing the effects of testosterone replacement therapy and placebo on lean mass, muscle strength, physical function, and aerobic performance. Graphs include whole body lean mass, appendicular lean mass and VO2 max.
Kaplan-Meier curve of overall symptom duration, comparing 'POCT test' and 'No POCT test' groups. The x-axis shows days, the y-axis shows the proportion recovered. The 'No POCT test' group shows a slightly higher recovery rate.
JAMA Internal Medicine study: Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy. Population: 30M/30F, median age 62.5y. Intervention: 68 randomized; 28 continue, 32 hold medication. Findings: Continue medication group had higher residual gastric volume, P=.003.
JAMA Internal Medicine presents "Artificial Intelligence and Bystander Cardiopulmonary Resuscitation—Pushing Forward" by Teva D. Brender@1, Sharon K. Inouye@2, Cary P. Gross@3. Published May 18, 2026. doi: 10.1001/jamainternmed.2026.1559
Bar graph comparing 911 dispatcher and CPR instructor agent performance in bystander CPR instruction. Checklist CPR guideline-concordant criteria satisfied (%) is charted for "Minimally viable" and "Maximally effective" criteria. P=.02 and P<.001 are given.
Box and whisker plots showing the effects of testosterone replacement therapy and placebo on lean mass, muscle strength, physical function, and aerobic performance. Graphs include whole body lean mass, appendicular lean mass and VO2 max.
Visual representation of PCOS clinical presentations across life stages. Adolescence: weight gain, irregular cycles, acne, hirsutism, and emotional distress. Early adulthood: overweight/obesity, metabolic and reproductive issues. Late adulthood: cancer risk, CVD.
JAMA Internal Medicine article titled "Life Expectancy in Chronic Obstructive Pulmonary Disease" with Kaplan-Meier survival curves comparing COPD stages & GOLD stages with survival probability over time, including "No. at risk" data. Published May 17, 2026.
JAMA Internal Medicine article titled "Life Expectancy in Chronic Obstructive Pulmonary Disease" with Kaplan-Meier survival curves comparing COPD stages & GOLD stages with survival probability over time, including "No. at risk" data. Published May 17, 2026.
Bar graph showing products with reduced patent protection. The X axis represents "Time after FDA approval, y" from 0 to 35. Each drug is represented by a horizontal bar indicating patent protection. Text: Stiolto Respimat, Striverdi Respimat, etc.
Box and whisker plots showing the effects of testosterone replacement therapy and placebo on lean mass, muscle strength, physical function, and aerobic performance. Graphs include whole body lean mass, appendicular lean mass and VO2 max.
JAMA Internal Medicine editorial, "Patent Listing Challenges by the Federal Trade Commission: A New Approach to Promoting Drug Affordability" by Anna Hung and Cary P. Gross. Published online: May 11, 2026. doi: text@1
Components for implementing a Contingency Management Program for Stimulant Use Disorder include target behavior, reinforcement schedule, delivery method, reward magnitude and type. Abbreviation: UDS, urine drug screen.
JAMA Internal Medicine presents an RCT on Diacerein for Knee Osteoarthritis. Population: 115 males, 147 females. Intervention: 262 patients randomized, 130 Diacerein, 128 Placebo. Settings: 4 hospitals in Australia. Graph shows WOMAC score vs follow-up in weeks.
Table: Foods With Higher and Lower Potassium Levels by Region and Ethnicity. Latin American/Caribbean: plantain vs chayote, African: yam vs okra, South Asian: tamarind vs snake gourd, East/Southeast Asian: durian vs bamboo shoots, etc.
Line graph titled 'Acute Care Burn Encounter Rates per 1000 Patients With Oregon Medicaid'. The graph shows acute care burn rates from Summer 2016 to Winter 2024 for any opioid, stimulants, any smokable drug, cannabis only, and no smokable drug.
Info sheet on anxiety disorders; lists generalized, social, panic, agoraphobia & specific phobias; suggests mindfulness, self-help, therapy, & medication. An illustration shows a woman with her hands on her head looking distressed.
A JAMA Internal Medicine promotion for the "Teachable Moment Editorial Fellowship" with applications due May 15, 2026. The background shows medical professionals reviewing documents. A "Learn more >" button is also present.
Bar graph showing effect of reduced time pressure on care delivery. Comprehensiveness of care is compared against preventive care. Adjusted difference for reduced vs regular time pressure visits is plotted. Text includes: text@1.
Box and whisker plots showing the effects of testosterone replacement therapy and placebo on lean mass, muscle strength, physical function, and aerobic performance. Graphs include whole body lean mass, appendicular lean mass and VO2 max.
A JAMA Internal Medicine promotion for the "Teachable Moment Editorial Fellowship" with applications due May 15, 2026. The background shows medical professionals reviewing documents. A "Learn more >" button is also present.
Info sheet on anxiety disorders; lists generalized, social, panic, agoraphobia & specific phobias; suggests mindfulness, self-help, therapy, & medication. An illustration shows a woman with her hands on her head looking distressed.
Flowchart: Anxiety Treatment Options. Clinical evaluation includes assessing history of present illness, physical/lab exams. Differential diagnosis covers subthreshold anxiety, other psychiatric disorders. Treatment: behavioral or pharmacotherapy.