Jeff Spence @jeffspence.github.io · Dec 17 But selection only cares about a variant because of how it impacts fitness-relevant traits. Under certain assumptions (see the paper!), we have that the strength of selection is the sum of effects across all fitness-relevant traits: s = Σₜ γₜ² www.biorxiv.org/content/10.1... 4/6
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But this means that what matters for association study ranking is how specific a variant’s effects are to the trait you’re studying! signal ~ μ γ² / Σₜ γₜ² The most important variants don't end up with the largest z-scores! 5/6