Jeff Spence @jeffspence.github.io · Dec 17 But this means that what matters for association study ranking is how specific a variant’s effects are to the trait you’re studying! signal ~ μ γ² / Σₜ γₜ² The most important variants don't end up with the largest z-scores! 5/6
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See our main thread about the paper 👇 for what this means about how we should interpret GWAS and rare variant burden tests! 6/6 bsky.app/profile/jeff...