Jeff Spence @jeffspence.github.io · Dec 17 What about GWAS? GWAS prioritize genes near trait-specific VARIANTS. This is profoundly different from prioritizing trait-specific GENES. Variants can be specific because they act on trait-specific genes, or because they act on pleiotropic genes in a context-specific way. 8/n
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We find that both of these ways of being specific contribute to variants being ranked highly in GWAS: 1) Coding variants in specifically-expressed genes are more highly ranked 2) Non-coding variants in tissue-specific ATAC peaks are more highly ranked 9/n