Jeff Spence @jeffspence.github.io · Dec 17 GWAS prioritize individual variants, and sometimes variants just happen to get lucky and drift to high frequencies. This plays a surprisingly large role in prioritization in simulated GWAS 14/n
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This randomness in variant frequencies also results in what seems a paradox: top GWAS hits are both more trait specific AND more likely to be hits for other traits! 15/n