Jeff Spence @jeffspence.github.io · Dec 17 This randomness in variant frequencies also results in what seems a paradox: top GWAS hits are both more trait specific AND more likely to be hits for other traits! 15/n
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Basically, when a variant gets lucky and drifts to high frequency, it is more likely to be a hit for every trait that it affects. This makes top hits APPEAR more pleiotropic, when in fact they’re actually LESS pleiotropic on average. 16/n