Jeff Spence @jeffspence.github.io · Dec 17 Basically, when a variant gets lucky and drifts to high frequency, it is more likely to be a hit for every trait that it affects. This makes top hits APPEAR more pleiotropic, when in fact they’re actually LESS pleiotropic on average. 16/n
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There’s a lot more in the paper! We started by saying that it would be nice to rank genes by importance or specificity, and showed that standard methods rank genes in part by specificity, not importance. Read the paper for suggestions on how to rank genes by importance. 17/n