Jeff Spence @jeffspence.github.io · Nov 7 Instead, one might want to rank genes by their trait SPECIFICITY -- how much do they affect the study trait relative to their effects across all traits. A trait-specific gene might be more "core" to trait biology. 7/n
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Using theory developed by @yuvalsim.bsky.social and @gs2747.bsky.social (journals.plos.org/plosbiology/...) we predicted that burden tests rank genes by SPECIFICITY! This is surprising! Burden tests DO NOT rank genes by IMPORTANCE! These predictions play out in the UKB. 8/n