Jeff Spence @jeffspence.github.io · Nov 7 What about GWAS? GWAS prioritize genes near trait-specific VARIANTS, whereas burden tests prioritize trait specific GENES. Variants can be specific because they act on trait-specific genes, or because they act on pleiotropic genes in a context-specific way. 10/n
6 likes 1 replies
?
Replies
Both of these ways of being specific contribute to variants being ranked highly in GWAS: 1. Coding variants in specifically-expressed genes are more highly ranked AND 2. Non-coding variants in tissue-specific ATAC peaks are more highly ranked. 11/n