Jenn Sydeski 🧬 📈 🩺 ⛑️

@jennifersydeski.com

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🌱Be the helpers, friends! Mr. Rogers is looking for you🌿 💙 Health Tech 🩻 Life Sciences 🧬🧪 AI 🤖 VR ᯅ Accessibility Advocacy ♿ Community Medical Care ⛑️ Mutual Aid 🤝 Supporting Moms 🦋 Nerdfighteria 🖖 Pittsburgh 🩵 www.jennifersydeski.com

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1. Feasibility of Personalized ctDNA Testing: The study demonstrates that personalized ctDNA assays can be developed and are feasible for monitoring metastatic ILC.

2. Early Detection of Relapse: ctDNA levels were found to rise before clinical or radiographic evidence of disease progression, indicating potential for early relapse detection.

3. Correlation with Treatment Response: Changes in ctDNA levels correlated with treatment responses, suggesting utility in monitoring therapeutic efficacy.

4. Potential for Personalized Monitoring: This approach underscores the potential of ctDNA testing as a personalized tool for disease monitoring in metastatic ILC patients.

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1. PHGDH's Dual Role: Traditionally recognized for its metabolic functions, PHGDH also regulates gene expression, influencing Alzheimer's disease progression.

2. AI-Powered Discovery: Utilizing AI, researchers identified PHGDH's structural similarity to transcription factors, unveiling its unexpected role in gene regulation.

3. Therapeutic Potential: Inhibiting PHGDH's transcriptional activity with a blood-brain barrier-permeable molecule reduced amyloid pathology in preclinical models.

4. Beyond Genetic Mutations: This finding highlights a non-genetic contributor to Alzheimer's, offering new hope for treatments targeting sporadic cases.

1. First In-Body CRISPR Treatment: Doctors successfully edited DNA inside a living patient, a baby with CPS1 deficiency, marking a significant medical milestone.

2. Rapid Development: The custom therapy was developed and approved in just six months, showcasing the potential for swift responses to rare genetic conditions.

3. Improved Health Outcomes: Post-treatment, the baby showed remarkable health improvements, including better protein tolerance and immune response.

4. Future of Personalized Medicine: This case paves the way for bespoke gene-editing therapies, potentially transforming treatment for countless rare genetic disorders.

1. Agency-Wide AI Integration: The FDA plans to deploy a unified, secure generative AI system across all centers by June 30, 2025, to streamline internal workflows.

2. Efficiency Gains from Pilot: A recent AI pilot demonstrated significant improvements in scientific review processes, prompting the accelerated rollout.

3. Leadership Endorsement: FDA Commissioner Martin Makary emphasized the importance of valuing scientists' time and reducing non-productive tasks through AI.

4. Focus on Therapeutic Acceleration: The initiative aims to expedite the evaluation of new therapies, benefiting patients by bringing treatments to market more swiftly.

1. Ultrasound-Activated Bioink: A new bioink remains liquid at body temperature but solidifies into desired structures when exposed to focused ultrasound, enabling precise internal tissue formation.

2. Non-Invasive Internal Printing: This technique allows for the creation of tissues, biosensors, and drug depots directly inside organs without surgical intervention, reducing risks and recovery time.

3. Real-Time Monitoring: The bioink includes components that respond to ultrasound, allowing scientists to monitor the printing process in real-time and ensure accurate placement.

4. Versatile Applications: Beyond tissue repair, this method has potential uses in targeted drug delivery and the creation of internal biosensors, marking a significant advancement in regenerative medicine.

1. Early Detection via Wastewater Sequencing: Measles virus was identified in wastewater samples on January 7, 2025, preceding confirmed clinical cases by ten days, showcasing the potential of wastewater surveillance for early outbreak detection.

2. High Sensitivity and Specificity: The sequencing-based method proved highly sensitive, detecting measles RNA in wastewater where no cases had been reported for over 31 months, and was validated through PCR testing.

3. Correlation with Clinical Cases: The presence of measles in wastewater corresponded with two infected travelers residing in the area, indicating the method's effectiveness in reflecting real-time community infections.

4. Public Health Implications: This approach offers a non-invasive, community-wide surveillance tool that can inform public health responses and interventions ahead of clinical case confirmations.

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Pittsburgh Science March 3-7-2025 11am Schenley Plaza

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Resume of Jenn Sydeski - read more at https://www.linkedin.com/in/jenniferlynsydeski/

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