Kevin Drew

@ksdrew.bsky.social

126 Followers 131 Following

Assistant Professor at University of Illinois at Chicago (UIC) in Biological Sciences focused on macromolecular assemblies.

OFD1 disease mutations (pink) cluster at the OFD1(green)-FOPNL(orange) interface.
The fraction of AlphaFold3 protein interaction models with high-confidence pDockQ pairs.
Comparison of enrichment for high-confidence pair interfaces out of the set of top confident pairs for DirectContacts2 and other networks. For each set, the fraction of high-confidence interfaces (pDockQ ≥ 0.5) out of their top predictions was calculated for increasing numbers of top predictions.
Precision recall analysis shows the DirectContacts2 model (purple) outperforms the HuRI network (yellow), hu.MAP2.0 (green), hu.MAP3.0 (orange), and the original Direct Contacts model (blue). A random shuffling of pairs is shown in gray. Analysis is performed on a benchmark of leave-out set of direct (positive) and indirect (negative) protein interactions derived from the PDB.
Image displays an illustrative, multi-subunit protein complex where some subunits directly interact (yellow and green subunits) while others indirectly interact through other subunits (magenta and green subunits).