Long COVID Labs

@longcovidlabs.bsky.social

303 Followers 113 Following

Non-profit accelerating a cure for 100M+ people with Long COVID. Longcovidlabs.org

Screenshot from Aug 5 presentation- questions are in next posts in this thread
Screenshot of announcement in Federal Register, found at https://www.federalregister.gov/documents/2026/06/11/2026-11691/drug-repurposing-for-unmet-medical-needs-request-for-information-extension-of-comment-period
screenshot of article title and microscopic coronavirus photo
Screenshot of article
Screenshot of article title and COVID test
Screenshot of article title and summary
Screenshot of article title and key points section
Screenshot from presentation explaining their hypothesis. Dysfunctional T cells clonally expand in response to a foreign or self antigen. This causes maladaptive reprogramming of CD8 T cells and disease due to impaired and/or sustained immunity
Figure 1 from the paper
Screenshot of title of article featuring photo of Dr Chopra in her office wearing a white lab coat
Screenshot of article title and abstract https://link.springer.com/article/10.1186/s12967-026-08081-6
diagram from the paper showing how events in the acute infection lead to sustained olfactory abnormality in Long COVID
Screenshot of title and abstract from this paper: https://www.biorxiv.org/content/10.64898/2026.03.31.715419v1
Screenshot of title, author info and background from this paper: https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/41768981
Screenshot of article title, background and objective from this paper: https://www.acpjournals.org/doi/10.7326/ANNALS-25-04883?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Screenshot of article title, author info, and abstract from this paper: https://www.biorxiv.org/content/10.64898/2026.02.28.708602v1
Screenshot of article title and headshots of 3 researchers who received awards, from this article: https://ldi.upenn.edu/our-work/research-updates/three-studies-by-ldi-senior-fellows-win-clinical-research-forum-awards/
Screenshot of article title from this page: https://www.biospace.com/press-releases/traws-pharma-reports-positive-interim-clinical-data-with-ratutrelvir-versus-paxlovid-shows-activity-in-paxlovid-ineligible-covid-19-patients
Screenshot of press release at https://www.health.gov.au/ministers/the-hon-mark-butler-mp/media/120-million-for-groundbreaking-medical-research?language=en Includes article title, and subtitle that reads $120 million for groundbreaking medical research Australia’s top health researchers will share in more than $120 million from the Medical Research Future Fund to deliver 60 innovative projects aimed at transforming prevention, diagnosis, treatment and care for Australians. Includes a photo of The Hon Mark Butler MP Minister for Health and Ageing Minister for Disability and the National Disability Insurance Scheme, a Causasian man wearing a navy suit and maroon tie.
Text says: Insightful comment from a member of our Long COVID Labs subreddit! 👇 We are just beginning to uncover the role viruses have played in our biology. Our focus is on COVID-19, but other viruses such as Epstein-Barr are likely at the root of many diseases! 🦠 While the impact of these diseases has been unspeakably devastating, we’re excited for the possibilities as science discovers new ways to prevent and treat these infections! 🙏
Screenshot of title and first paragraph from this post: https://longcovidweekly.substack.com/p/long-covid-weekly-165-brain-fog-arrhythmias
Screenshot of email from a patient. Text says: “With the wind seemingly against us so long; this incredible gift is truly a Christmas miracle. I’ll keep you posted. With gratitude.”
Audiogram featuring Rohan and Jorge speaking on the podcast. The image is a purple and blue themed illustration of planet Earth against a black background.
Screenshot of the title and author info from this paper: https://www.nature.com/articles/s41533-025-00460-8
Screenshot of title and author information from this paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC12607243/
Screenshot of a Gmail inbox. The top email reads: From: App Store Connect Subject: Thank you for submitting your app - We’ve received your app for review. LONG COVID LABS MOONSHO (and then it gets cut off)
photo of Rohan standing on a stage, next to a podium, and holding a microphone. An image of him speaking is projected onto a large screen, above the d/acc discovery day logo. The graphics are purple and blue- themed.
Infographic showing a purple-themed illustration of a planet, set against a black background. In light green text it says: Long COVID LABS x WCG IRB World's First IRB-Approved Patient Registry to Reward Participants with Blockchain Tokens
Screenshot of the first 2 paragraphs of the article. Text says: If you think the COVID pandemic is done and ever-evolving variants pose no significant threat, consider these two realities. The first is a recent U.S. study published in the Journal of the American Medical Association. It tracked 150 million workers and their absences in the workplace in the United States since the end of the so-called public health emergency in 2023. Its central conclusion: “Health-related absences from work continued to track COVID-19 circulation and were 12.9 per cent higher in the post-pandemic period compared with before the pandemic (140,000 monthly absences).” Absences were highest in occupations with the greatest exposure to the public.
Screenshot of the "pathophysiology" section from the paper at: https://journals.lww.com/tnpj/fulltext/2025/11000/an_overview_of_clinical_presentation_and.9.aspx
Screenshot of article title and author info from the paper here: https://www.researchsquare.com/article/rs-7483367/v1 Title is: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients using a microfluidic assay
Screenshot of article title, author info, and abstract from this paper: https://www.tandfonline.com/doi/full/10.1080/25785826.2025.2570902#d1e608 Titled: "Long COVID: mechanisms of disease, multisystem sequelae, and prospects for treatment"
Figure 4B from the paper - graph showing viral clearance rates over 7 days. Ritonavir- boosted nirmaltrelvir decreases the most sharply, to just over 50% of patients with symptoms at 7 days, while ensitlrevr's recovery rates remain slightly higher. The no-treatment group persistently maintains a higher % of symptoms. Paper here: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00482-7/fulltext
Figure 4 from the paper at https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1623390/full Caption says: Figure 4. A schematic representation of the Spike mutations in the patient K sample and their overlap with the mutations that were also observed in the ancestors of VOCs, previously described mutations found in chronic infections, associated with immune evasion, or overrepresented in wastewater samples (see Table 1 for corresponding references). Spike domain coordinates were obtained from ref (Shrivastava et al., 2021).
Screenshot of title and author info from this paper: https://www.mdpi.com/1999-4915/17/9/1170
Figure 1 from the paper: Caption says: Five major mechanisms by which the virus, vRNA, and viral antigens may cause multiple and different pathologies in Long COVID patients. (A) A causative factor in a large subset of patients with LC is that reservoirs of virus, viral RNA (vRNA), and/or fragments may persist in multiple sites of the body. (B) This causes chronic inflammation, overstimulating innate and adaptive immune cells, and providing continuous viral antigenic stimuli to (C) exhausted CD4+ and CD8+ T cells [31,33,34,35,36]. This may result in damage to major organ systems, leading to neurological, cardiovascular, pulmonary, muscular, and psychiatric pathologies [43,44]. (D–F) Other possible causative factors of LC include metabolic disturbances, immune dysbiosis, micro-clotting, endothelial dysfunction [38,43,45,46,47], and the reactivation of HSV-1, HSV-2, EBV, CMV, and HHV-6 [48,49]. This Figure is created using BioRender.
Screenshot of Amy’s quote. Attributed to Amy Mitchell, Long Covid Action Project
Screenshot of Charlie's quote attributed to Charlie McCone, Patient Led Research Collaborative
Screenshot from Sick Times article: Screenshot of the article title and text box from the article at https://thesicktimes.org/2025/09/09/recover-tlc-announces-new-long-covid-clinical-trials-receives-mixed-reactions-from-patient-community/ Article title is: RECOVER-TLC announces new Long COVID clinical trials, receives mixed reactions from patient community Text box says: Key points you should know: RECOVER-Treating Long COVID (TLC) announced new clinical trials at the initiative’s second annual workshop. TLC is an offshoot of the broader $1.8 billion RECOVER program, run by the National Institutes of Health (NIH).
Screenshot from conference website. There is a photo of Boston featuring the Charles River with sailboats and skyscrapers in the background. Dates are Nov 19-20 location is hybrid and Boston US
Screenshot of article title and author info from this paper: https://www.researchsquare.com/article/rs-7500476/'https://www.researchsquare.com/article/rs-7500476/v1
Futuristic image of a woman in a hospital gown sitting in a padded office chair while hooked up to an IV. She appears to be on an office setting with computer screens and skyscrapers in the background.
Futuristic image of two people holding hands. One person has a watch and a tattoo on the underside of their wrist. The other appears to have some sort of tattoo on their forearm. The image is pink- and purple- themed and there is a cityscape in the background.
Futuristic pink- and purple- themed image showing a museum-like building sitting on a metaphorical board surrounded by other objects, such as a flask and a cell phone. One possible interpretation is that it's supposed to represent planning towards future goals.
Photo of LC Labs founder Rohan Dixit speaking at the DeSci Berlin conference earlier this year.
Purple-themed graphic with the text "Weekly Update" and "Here's what happened this week." The text is superimposed over a dark blue background with a computer-generated microscopic image of DNA. The Long COVID Labs logo is at the bottom.
Infographic labeled "Long COVID: A Global Health Challenge" showing human figures scattered across the globe. Subtitle says "Over 100 Million Cases"
Screenshot of article title and photo of scientist Janna Moen working over a Petri dish Article here: https://www.washingtonpost.com/wellness/2025/07/09/long-covid-lessons-future-pandemics/ What long covid can teach us about future pandemics - The Washington Post
Purple-themed graphic of two people holding hands
Photo of healthy control ( a smiling man with blond hair) seated at a desk. He's giving the thumbs up sign. A mobile phlebotomist in a lab coat and gloves, with face blurred, is drawing the man's blood into a test tube.
Purple themes Image of Discord logo floating above a pool with a cityscape in the background
Video of Rohan having his blood drawn by a mobile phlebotomist. He is seated outside at a patio table. He and the phlebotomist are both wearing masks.
Screenshot from article header. Article is titled “discover explains long covid breathing problems” and features a photo of the research team. Article can be found at: https://newsroom.uvahealth.com/2025/05/02/discovery-explains-long-covid-breathing-problems/
Photo of Paul standing at a podium with a microphone while the audience is seated in front of him. An image of a LC Labs tweet featuring our first patient in a case study is projected onto the wall behind him
Info graphic that says DeSci Berlin with a formal museum-type building in the background. Shows the date of DeSci Berlin June 10-11 Invitations to follow us on X, community discord, and Reddit https://www.reddit.com/r/LongCovidTrials/s/AVidjlGJJP
Infographic titled "Patient Registry and Data Bank: Empowering Research Through Shared Data" Shows a metaphorical flow chart with input from people, smart watches, a clipboard, and a DNA, transforming into a chart, medication, blood samples, and ultimately ending up in a secure data vault.
Graph showing Patient #1's STOP-PASC scores fluctuating over time. Pre-infusion, his score fluctuated around 8-9. In the week following the infusion, it fell to 3, then rose to 18 two weeks after the infusion. Over the final two weeks in the chart, it fell to 13, ending on May 24.
Graph showing Patient #1's STOP-PASC scores fluctuating over time. Pre-infusion, his score fluctuated around 8-9. In the week following the infusion, it fell to 3, then rose to 18 two weeks after the infusion. Over the final two weeks in the chart, it fell to 13, ending on May 24.